Evidence map›Paper›PMID 33290039›Full record

ArticleACS nano2020

Controlled Dendrimersome Nanoreactor System for Localized Hypochlorite-Induced Killing of Bacteria.

Michael Potter, Adrian Najer, Anna Klöckner, Shaodong Zhang, Margaret N Holme, Valeria Nele, Junyi Che, Lucia Massi, Jelle Penders, Catherine Saunders and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Review
  6. Review
  7. Review
  8. Complex Energy Landscapes of Self-Assembled Vesicles.Journal of the American Chemical Society · 2023
    Article
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  10. Article
  11. Article
  12. Article
  13. Wearable Bioelectronics for Chronic Wound Management.Advanced functional materials · 2022
    Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Michael PotterDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.ORCID 0000-0003-4688-6874
Adrian NajerDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.ORCID 0000-0003-4868-9364
Anna KlöcknerDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
Shaodong ZhangDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.ORCID 0000-0001-7923-8457
Margaret N HolmeDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.ORCID 0000-0002-7314-9493
Valeria NeleDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
Junyi CheDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
Lucia MassiDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
Jelle PendersDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.ORCID 0000-0002-5232-917X
Catherine SaundersDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.
James J DoutchRutherford Appleton Laboratory, ISIS Neutron and Muon Source, STFC, Didcot OX11 ODE, U.K.
Andrew M EdwardsMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, U.K.
Oscar CesDepartment of Chemistry and Institute of Chemical Biology, Imperial College London, Molecular Sciences Research Hub, London W12 0BZ, U.K.
Molly M StevensDepartment of Materials, Department of Bioengineering, and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, U.K.ORCID 0000-0002-7335-266X
Imperial College London · GBInstitute of Structural and Molecular Biology · GBKarolinska Institutet · SERutherford Appleton Laboratory · GB

Funding

Medical Research Council MR/P028225/1NIAID NIH HHS HHSN272200700055CWellcome Trust 209121/Z/17/Z
6 · The paper itself

Abstract

Antibiotic resistance is a serious global health problem necessitating new bactericidal approaches such as nanomedicines. Dendrimersomes (DSs) have recently become a valuable alternative nanocarrier to polymersomes and liposomes due to their molecular definition and synthetic versatility. Despite this, their biomedical application is still in its infancy. Inspired by the localized antimicrobial function of neutrophil phagosomes and the versatility of DSs, a simple three-component DS-based nanoreactor with broad-spectrum bactericidal activity is presented. This was achieved by encapsulation of glucose oxidase (GOX) and myeloperoxidase (MPO) within DSs (GOX-MPO-DSs), self-assembled from an amphiphilic Janus dendrimer, that possesses a semipermeable membrane. By external addition of glucose to GOX-MPO-DS, the production of hypochlorite (

Indexed as

bactericidalcascade nanoreactordendrimersomesemipermeabletoxin-activation

Identifiers

PMID33290039
PMCPMC7760217
OpenAlexW3111385075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.