ReviewMolecular biology reports2021
Pathological mechanism of joint destruction in haemophilic arthropathy.
Review in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Global trends in hemophilic arthropathy research: a bibliometric and visualization analysis.Frontiers in medicine · 2025Pooled it
- Effectiveness of physical exercise on postural balance in patients with haemophilia: A systematic review.Haemophilia : the official journal of the World Federation of Hemophilia · 2022Pooled it
- Iron as a Key Mediator of Chronic Joint Damage: Insights from Hemophilic Arthropathy and Implications for Osteoarthritis.Medicina (Kaunas, Lithuania) · 2026Review
- Article
- The Epigenetic Landscape of Hemophilia.Current molecular medicine · 2026Review
- Eight-Week Resistance Training and Manual Therapy in Young Patients with Severe Hemophilia: A Case Series Evaluating Functional, Imaging, and Immunological Outcomes.Journal of clinical medicine · 2025Article
- The prediction of haemophilic arthropathy progression based on MRI findings and clinical characteristics.Orphanet journal of rare diseases · 2025Article
- Decision experiences in joint replacement surgery for patients with haemophilic arthritis: A qualitative study.BMC medical informatics and decision making · 2025Article
- CORR Insights®: Total Shoulder Arthroplasty in Patients With Hemophilia A: Greater Odds of Postoperative Bleeding and Thromboembolic Events but No Difference in 5-year Implant Survival.Clinical orthopaedics and related research · 2025Article
- Influencing factors of the outcome of patients with haemophilia after knee replacement-a retrospective study.BMC musculoskeletal disorders · 2025Article
- How much preoperative ROM and FC is a predictor for poor result after total knee arthroplasty in hemophilic arthropathy?Frontiers in surgery · 2025Article
- Outcome measures analysis following total knee arthroplasty in patients with severe haemophilic arthropathy of the knee.Biomedical reports · 2024Article
- Cartilage Destruction by Hemophilic Arthropathy Can Be Prevented by Inhibition of the Ferroptosis Pathway in Human Chondrocytes.Journal of clinical medicine · 2024Article
- Quality of life in children and adolescents with blood coagulation disorders and hemoglobinopathies.Brazilian oral research · 2024Article
- Physical therapy for end-stage hemophilic arthropathy: a case report.BMC musculoskeletal disorders · 2023Article
- Osteoporosis and associated risk factors in patients with severe hemophilia A: a case-control study from China.BMC musculoskeletal disorders · 2023Article
- The potential role of protease systems in hemophilic arthropathy.Blood advances · 2022Article
- Study on the morphological characteristics and rotational alignment axis of placement plane of the tibial component in total knee arthroplasty for hemophilia-related knee arthritis.Journal of orthopaedic surgery and research · 2022Article
- Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression.Frontiers in medicine · 2022Review
- Use of the Multidimensional Haemophilia Pain Questionnaire (MHPQ) in Patients With Severe Haemophilia A Treated With Emicizumab: A Pilot Cross-Sectional, Single-Centre Study.Haemophilia : the official journal of the World Federation of HemophiliaArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Haemophilic arthropathy (HA), caused by intra-articular haemorrhage, is one of the most common complications in patients with haemophilia. Factor replacement therapy provides missing coagulation factors to prevent children with haemophilia from joint bleeding and decreases their risk for HA. However, haemophilia patients in developing countries are still suffering from HA due to insufficient replacement therapy. Symptoms such as pain and activity limitations caused by HA seriously affect the functional abilities and quality of life of patients with HA, causing a high disability rate in the haemophilia cohort. The pathological mechanism of HA is complicated because the whole pathological mainly involves hypertrophic synovitis, osteopenia, cartilage and bone destruction, and these pathological changes occur in parallel and interact with each other. Inflammation plays an important role in the whole complex pathological process, and iron, cytokines, growth factors and other factors are involved. This review summarizes the pathological mechanism of HA to provide background for clinical and basic research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.