ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2021
Health-related quality of life and overall survival: a prospective study in patients with head and neck cancer treated with radiotherapy.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pre-treatment quality of life and survival outcomes in lung cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Systematic review and standardized comparison of health-related quality-of-life instruments available for patients with oral cavity cancer and oropharyngeal cancer.BMC oral health · 2025Pooled it
- Health-related quality of life in Her2-positive early breast cancer woman using trastuzumab: A systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Trial
- Dynamic Quality-of-Life Trajectories After Head and Neck Reconstruction.JAMA otolaryngology-- head & neck surgery · 2026Article
- Unmet supportive care needs among head and neck cancer survivors in China: multicenter cross-sectional study.Frontiers in public health · 2026Article
- Associations Between Ostomy Creation and Health-Related Quality of Life in Colorectal Cancer Patients: A Longitudinal Observational Study.Cancer medicine · 2025Observational
- Health-Related Quality of Life in Patients With a Head and Neck Sarcoma: A Mixed-Methods Study.Head & neck · 2025Article
- Oral rehabilitation and quality of life in head and neck cancer patients receiving dental clearance prior to radiotherapy: a retrospective observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- Impact of Face Mask-Wearing on Quality of Life in Post-Surgical Oral Cancer Patients: A Cross-Sectional Study.Cancers · 2024Article
- Longitudinal assessment of quality of life indicators and prognosis in esophageal cancer patients with curative resection.Journal of thoracic disease · 2024Article
- Joint modeling of longitudinal health-related quality of life during concurrent chemoradiotherapy period and long-term survival among patients with advanced nasopharyngeal carcinoma.Radiation oncology (London, England) · 2024Article
- Risk Factors for Bisphosphonate-Related Osteonecrosis of the Jaws in Bone Metastatic Breast and Prostate Cancer under Zoledronate Treatment: A Retrospective Analysis from 10 Years of Evaluation.Asian Pacific journal of cancer prevention : APJCP · 2023Observational
- Effects of exercise interventions on cancer-related fatigue and quality of life among cancer patients: a meta-analysis.BMC nursing · 2023Article
- Dysphagia and shortness-of-breath as markers for treatment failure and survival in oropharyngeal cancer after radiation.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Article
- SOX2 promotes a cancer stem cell-like phenotype and local spreading in oral squamous cell carcinoma.PloS one · 2023Article
- Factors important for health-related quality of life in men and women: The population based SCAPIS study.PloS one · 2023Article
- Postoperative external beam radiotherapy for locoregional control in iodine refractory differentiated thyroid cancer.European thyroid journal · 2022Article
- Functional Shoulder Outcome and Quality of Life Following Modified Muscle-Sparing Pectoralis Major Flap Surgery.Healthcare (Basel, Switzerland) · 2021Article
- Resection Margins in Head and Neck Cancer Surgery: An Update of Residual Disease and Field Cancerization.Cancers · 2021Review
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Authors and funding
7 authors.
Funding
Abstract
purposeWe aimed to examine whether pre-treatment, post-treatment and change in health-related quality of Life (HRQoL) is associated with survival, in patients with head and neck cancer (HNC).
methodsWe included 948 newly diagnosed HNC patients treated with primary or adjuvant (chemo)radiotherapy with curative intent. The EORTC QLQ-C30 questionnaire was assessed pre-treatment and at 6 weeks, 6 months and 12 months post-treatment. Multivariable Cox regression analyses were performed to examine whether HRQoL at all time points and changes in HRQoL over time were associated with survival, after adjusting for demographic, clinical and lifestyle-related variables.
resultsHigher HRQoL scores were significantly associated with improved 5-year overall survival at all time points, except for the subscale global QoL at 6 weeks. Changes in HRQoL at 6 weeks post-treatment compared to pre-treatment were not significantly associated with survival. Changes in physical (HR: 0.88 95% CI: 0.82-0.96) and emotional functioning (HR: 0.90 95% CI: 0.85-0.96) from pre-treatment to 6 months post-treatment and changes in global QOL, and physical, emotional, and social functioning from pre-treatment to 12 months post-treatment were significantly associated with survival.
conclusionHigher HRQoL reported pre-treatment and post-treatment (6 weeks, 6 months and 12 months) are significantly associated with improved survival, as well as changes in HRQoL at 6 and 12 months compared to pre-treatment. Our results highlight the value of monitoring HRQoL and to identify those patients that report decreased or deteriorated HRQOL. This may help to further improve cancer care in a timely and efficient manner.
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