ArticleAging2020
Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Human clinical trial of plasmapheresis effects on biomarkers of aging (efficacy and safety trial).Scientific reports · 2025Trial
- Climate Change, Epigenetics, Microbiota, and Health.International journal of environmental research and public health · 2026Review
- Long-term exposure to ambient air pollution and epigenetic age acceleration in children.American journal of epidemiology · 2025Article
- Accelerated transcriptomic age and susceptibility to traffic-related air pollution among cardiac catheterization patients.The Science of the total environment · 2025Article
- Neighborhood Opportunity and Biological Aging: Results From the Midlife in the United States.Biopsychosocial science and medicine · 2025Article
- Environmental public health research at the U.S. Environmental Protection Agency: A blueprint for exposure science in a connected world.Journal of exposure science & environmental epidemiology · 2025Review
- The Joint Effects of Exposure to Ambient Long-term Air Pollution and Short-term Heat on Epigenetic Aging in the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Environmental and Climate Impacts on Physiological Aging: Comprehensive Pathways to Enhanced Age-related Resilience.Aging and disease · 2024Article
- Article
- Speeding Up Time: New Urinary Peptide Clock Associates Greater Air Pollution Exposures with Faster Biological Aging.Environmental health perspectives · 2024Article
- Challenges and opportunities for research supporting cumulative impact assessments at the United States environmental protection agency's office of research and development.Lancet regional health. Americas · 2024Review
- Accelerated aging and altered subclinical response to ozone exposure in young, healthy adults.Environmental epigenetics · 2024Article
- Bronchial cell epigenetic aging in a human experimental study of short-term diesel and ozone exposures.Environmental epigenetics · 2024Article
- Redefining exposure science to advance research supporting cumulative impacts, environmental justice, and decision-making.Journal of exposure science & environmental epidemiology · 2023Article
- Associations between medium- and long-term exposure to air temperature and epigenetic age acceleration.Environment international · 2023Article
- Epigenetics of Early Cardiometabolic Disease: Mechanisms and Precision Medicine.Circulation research · 2023Review
- The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes.Clinical epigenetics · 2022Article
- The Impact of Air Pollution on Residents' Happiness: A Study on the Moderating Effect Based on Pollution Sensitivity.International journal of environmental research and public health · 2022Article
- Impacts of Environmental Insults on Cardiovascular Aging.Current environmental health reports · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundAccelerated epigenetic age has been proposed as a biomarker of increased aging, which may indicate disruptions in cellular and organ system homeostasis and thus contribute to sensitivity to environmental exposures.
methodsUsing 497 participants from the CATHGEN cohort, we evaluated whether accelerated epigenetic aging increases cardiovascular sensitivity to traffic-related air pollution (TRAP) exposure. We used residential proximity to major roadways and source apportioned air pollution models as measures of TRAP exposure, and chose peripheral arterial disease (PAD) and blood pressure as outcomes based on previous associations with TRAP. We used Horvath epigenetic age acceleration (AAD) and phenotypic age acceleration (PhenoAAD) as measures of age acceleration, and adjusted all models for chronological age, race, sex, smoking, and socioeconomic status.
resultsWe observed significant interactions between TRAP and both AAD and PhenoAAD. Interactions indicated that increased epigenetic age acceleration elevated associations between proximity to roadways and PAD. Interactions were also observed between AAD and gasoline and diesel source apportioned PM
conclusionEpigenetic age acceleration may be a biomarker of sensitivity to air pollution, particularly for TRAP in urban cohorts. This presents a novel means by which to understand sensitivity to air pollution and provides a molecular measure of environmental sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.