Evidence map›Paper›PMID 33289681›Full record

ArticleCurrent issues in molecular biology2021

Human and Veterinary Vaccines for Lyme Disease.

Nathaniel S O'Bier, Amanda L Hatke, Andrew C Camire, Richard T Marconi

Open access · goldAbstract read
In one paragraph

Article in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. OspA antibodies inhibit theInfection and immunity · 2026
    Article
  2. Article
  3. The Lyme Disease Vaccine Paradox.Journal of clinical medicine · 2026
    Article
  4. Article
  5. A Lyme disease mRNA vaccine targetingMolecular therapy. Nucleic acids · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. A single immunization ofInfection and immunity · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Frontiers in cellular and infection microbiology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nathaniel S O'BierDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA.
Amanda L HatkeDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA.
Andrew C CamireDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA.
Richard T MarconiDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298, USA.
Virginia Commonwealth University Medical Center · US

Funding

Chimeric epitope based vaccines for tick borne infectionsR01AI141801 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARCONI, RICHARD T · 2019 to 2022
$2.5M
Development of a polyvalent chimeric vaccine for Lyme diseaseR01AI067746 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARCONI, RICHARD T · 2006 to 2010
$1.7M
Development of a multi-pathogen chimeritope vaccine for tick borne diseasesR56AI127801 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARCONI, RICHARD T · 2017 to 2017
$510k
NIAID NIH HHS R01 AI067746NIAID NIH HHS R01 AI141801NIAID NIH HHS R56 AI127801
6 · The paper itself

Abstract

Lyme disease (LD) is an emerging zoonotic infection that is increasing in incidence in North America, Europe, and Asia. With the development of safe and efficacious vaccines, LD can potentially be prevented. Vaccination offers a cost-effective and safe approach for decreasing the risk of infection. While LD vaccines have been widely used in veterinary medicine, they are not available as a preventive tool for humans. Central to the development of effective vaccines is an understanding of the enzootic cycle of LD, differential gene expression of

Indexed as

AnimalsBorrelia burgdorferiDisease ReservoirsDisease SusceptibilityGlobal HealthHumansLyme DiseaseLyme Disease VaccinesPopulation SurveillanceVaccinationLyme Disease Vaccines

Identifiers

PMID33289681
PMCPMC7946718
OpenAlexW3092468126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.