Evidence map›Paper›PMID 33289666›Full record

ArticleInternational journal of radiation oncology, biology, physics2021

Melanoma Cell Intrinsic GABA

Daniel A Pomeranz Krummel, Tahseen H Nasti, Milota Kaluzova, Laura Kallay, Debanjan Bhattacharya, Johannes C Melms, Benjamin Izar, Maxwell Xu, Andre Burnham, Taukir Ahmed and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

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  19. Therapeutically leveraging GABAExperimental biology and medicine (Maywood, N.J.) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Daniel A Pomeranz KrummelDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Tahseen H NastiDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia.
Milota KaluzovaEmory University School of Medicine, Atlanta, Georgia.
Laura KallayDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Debanjan BhattacharyaDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Johannes C MelmsColumbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons, New York, New York.
Benjamin IzarColumbia Center for Translational Immunology, Columbia University College of Physicians and Surgeons, New York, New York.
Maxwell XuJohns Hopkins University, Baltimore, Maryland.
Andre BurnhamEmory University School of Medicine, Atlanta, Georgia.
Taukir AhmedDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
Guanguan LiDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
David LawsonDepartment of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.
Jeanne KowalskiDepartment of Oncology, LIVESTRONG Cancer Institutes, Dell Medical School, University of Texas, Austin, Texas.
Yichun CaoBiostatistics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, Georgia.
Jeffrey M SwitchenkoBiostatistics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, Georgia; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Dan IonascuDepartment of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
James M CookDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
Mario MedvedovicDepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Andrew JenkinsDepartments of Anesthesiology, Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia.
Mohammad K KhanDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.
Soma SenguptaDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: sengupsm@ucmail.uc.edu.
Emory University · USUniversity of Cincinnati Medical Center · USUniversity of Wisconsin–Milwaukee · USColumbia University · USJohns Hopkins University · USLivestrong Foundation · US

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule DrugsU54CA225088 · NCI · HARVARD MEDICAL SCHOOL · PI SORGER, PETER KARL · 2018 to 2022
$10.8M
Dissecting mechanisms of immunotherapy resistance in melanoma patientsK08CA222663 · NCI · DANA-FARBER CANCER INST · PI IZAR, BENJAMIN · 2017 to 2021
$827k
Elucidating Signaling Pathways for GABA-A Receptor Alpha5 in an Aggressive Subtype of MedulloblastomasK08NS083626 · NINDS · EMORY UNIVERSITY · PI SENGUPTA, SOMA · 2014 to 2018
$741k
NCI NIH HHS K08 CA222663NCI NIH HHS P30 CA138292NCI NIH HHS U54 CA225088NINDS NIH HHS K08 NS083626
6 · The paper itself

Abstract

purposeMost patients with metastatic melanoma show variable responses to radiation therapy and do not benefit from immune checkpoint inhibitors. Improved strategies for combination therapy that leverage potential benefits from radiation therapy and immune checkpoint inhibitors are critical. METHODS AND MATERIALS: We analyzed metastatic melanoma tumors in the TCGA cohort for expression of genes coding for subunits of type A γ-aminobutyric acid (GABA) receptor (GABA

resultsGenes coding for subunits of GABA

conclusionsThis study identifies an antitumor strategy combining radiation and/or an immune checkpoint inhibitor with modulation of GABA

Indexed as

AnimalsBenzodiazepinesCell ProliferationCombined Modality TherapyFemaleHumansImmune Checkpoint InhibitorsMelanomaMembrane ProteinsMiceMice, Inbred C57BLRadiation-Sensitizing AgentsReceptors, GABA-AT-LymphocytesBenzodiazepinesCKAP4 protein, humanImmune Checkpoint InhibitorsMembrane ProteinsQH-II-66Radiation-Sensitizing AgentsReceptors, GABA-A

Identifiers

PMID33289666
PMCPMC8329598
OpenAlexW3094148619

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.