ArticleeLife2020
Three rules govern thalamocortical connectivity of fast-spike inhibitory interneurons in the visual cortex.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 25 citations in OpenAlex.
- Fast-Spike Interneurons in Visual Cortical Layer 5: Heterogeneous Response Properties Are Related to Thalamocortical Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Retinal direction of motion is reliably transmitted to visual cortex through highly selective thalamocortical connections.Current biology : CB · 2025Article
- Binocular receptive-field construction in the primary visual cortex.Current biology : CB · 2024Article
- Visual Corticotectal Neurons in Awake Rabbits: Receptive Fields and Driving Monosynaptic Thalamocortical Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Efficient mapping of the thalamocortical monosynaptic connectivity in vivo by tangential insertions of high-density electrodes in the cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Physiological features of parvalbumin-expressing GABAergic interneurons contributing to high-frequency oscillations in the cerebral cortex.Current research in neurobiology · 2024Review
- Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo.eLife · 2023Article
- Article
- High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons.Nature communications · 2022Article
- Pooling strategies in V1 can account for the functional and structural diversity across species.PLoS computational biology · 2022Article
- A theory of cortical map formation in the visual brain.Nature communications · 2022Article
- Like a clock in the rabbit's visual cortex.eLife · 2021Article
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4 authors at 1 institution in 1 country.
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Abstract
Some cortical neurons receive highly selective thalamocortical (TC) input, but others do not. Here, we examine connectivity of single thalamic neurons (lateral geniculate nucleus, LGN) onto putative fast-spike inhibitory interneurons in layer 4 of rabbit visual cortex. We show that three 'rules' regulate this connectivity. These rules concern: (1) the precision of retinotopic alignment, (2) the amplitude of the postsynaptic local field potential elicited near the interneuron by spikes of the LGN neuron, and (3) the interneuron's response latency to strong, synchronous LGN input. We found that virtually all first-order fast-spike interneurons receive input from nearly all LGN axons that synapse nearby, regardless of their visual response properties. This was not the case for neighboring regular-spiking neurons. We conclude that profuse and highly promiscuous TC inputs to layer-4 fast-spike inhibitory interneurons generate response properties that are well-suited to mediate a fast, sensitive, and broadly tuned feed-forward inhibition of visual cortical excitatory neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.