Evidence map›Paper›PMID 33289628›Full record

ArticleeLife2020

Functionally specialized human CD4

Sofya A Kasatskaya, Kristin Ladell, Evgeniy S Egorov, Kelly L Miners, Alexey N Davydov, Maria Metsger, Dmitry B Staroverov, Elena K Matveyshina, Irina A Shagina, Ilgar Z Mamedov and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 26 citations in OpenAlex.

  1. Gliadin-specific CD4Science advances · 2026
    Article
  2. Article
  3. T Cell Thoughts.Immunological reviews · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Demonstration of T-Cell Monotypia Using Anti-TCRbeta1/2 (Diagnostics (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Innate-like T cell subset commitment in the murine thymus is independent of TCR characteristics and occurs during proliferation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. SARS-CoV-2-specific CD4iScience · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Sofya A Kasatskaya *Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russian Federation.
Kristin Ladell *Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Evgeniy S EgorovGenomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation.
Kelly L MinersDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Alexey N DavydovAdaptive Immunity Group, Central European Institute of Technology, Brno, Czech Republic.
Maria MetsgerAdaptive Immunity Group, Central European Institute of Technology, Brno, Czech Republic.
Dmitry B StaroverovGenomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation.
Elena K MatveyshinaFaculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russian Federation.ORCID 0000-0003-4641-4906
Irina A ShaginaGenomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation.
Ilgar Z MamedovGenomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation.
Mark IzraelsonGenomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation.
Pavel V ShelyakinCenter of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russian Federation.
Olga V BritanovaGenomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation.
David A Price *Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.ORCID 0000-0001-9416-2737
Dmitriy M Chudakov *Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russian Federation.ORCID 0000-0003-0430-790X
Pirogov Russian National Research Medical University · RUSkolkovo Institute of Science and Technology · RUCardiff University · GBCentral European Institute of Technology · CZInstitute of Bioorganic Chemistry · RU

Funding

Ministry of Science and Higher Education 075-15-2019-1789Ministry of Science and Higher Eductaion of Russian Federation 075-15-2019-1789Wellcome TrustWellcome Trust 100326/Z/12/Z
6 · The paper itself

Abstract

The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4

Indexed as

CD4-Positive T-LymphocytesCell LineageHumansReceptors, Antigen, T-Cell, alpha-betaT-Lymphocyte SubsetsReceptors, Antigen, T-Cell, alpha-betaCDR3 propertieshelper CD4+ subsetshumanimmunologyinflammationplasticity of CD4+ subsetsTCR repertoire

Identifiers

PMID33289628
PMCPMC7773335
OpenAlexW3112387972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.