Evidence map›Paper›PMID 33289611›Full record

ArticleRadiology2021

Improved Task-based Functional MRI Language Mapping in Patients with Brain Tumors through Marchenko-Pastur Principal Component Analysis Denoising.

Benjamin Ades-Aron, Gregory Lemberskiy, Jelle Veraart, John Golfinos, Els Fieremans, Dmitry S Novikov, Timothy Shepherd

Open access · greenAbstract read
In one paragraph

Article in Radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

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  5. Robust-tedana: An automated denoising pipeline for multi-echo fMRI data.bioRxiv : the preprint server for biology · 2025
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  14. Tensor denoising of multidimensional MRI data.Magnetic resonance in medicine · 2023
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  16. Efficient PCA denoising of spatially correlated redundant MRI data.Imaging neuroscience (Cambridge, Mass.) · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Benjamin Ades-AronFrom the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.).ORCID 0000-0001-5077-3341
Gregory LemberskiyFrom the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.).ORCID 0000-0002-8336-7486
Jelle VeraartFrom the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.).ORCID 0000-0003-0781-0420
John GolfinosFrom the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.).
Els FieremansFrom the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.).ORCID 0000-0002-1384-8591
Dmitry S NovikovFrom the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.).
Timothy ShepherdFrom the Center for Biomedical Imaging, Department of Radiology (B.A.A., G.L., J.V., E.F., D.S.N., T.S.) and Department of Neurosurgery (J.G.), New York University School of Medicine, 2nd Floor, 660 First Ave, New York, NY 10016; and Department of Electrical and Computer Engineering, New York University Tandon School of Engineering, New York, NY (B.A.A.).ORCID 0000-0003-0232-1636
New York University · US

Funding

Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
Mesoscopic Biomarkers of Neurodegeneration with Diffusion MRIR01NS088040 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS, NOVIKOV, DMITRY S · 2014 to 2023
$5.2M
Random Matrix Theory-Based Noise Removal in MRIR01EB027075 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FIEREMANS, ELS, NOVIKOV, DMITRY S · 2019 to 2022
$2.7M
NIA NIH HHS P30 AG066512NIBIB NIH HHS P41 EB017183NIBIB NIH HHS R01 EB027075NINDS NIH HHS R01 NS088040
6 · The paper itself

Abstract

Background Functional MRI improves preoperative planning in patients with brain tumors, but task-correlated signal intensity changes are only 2%-3% above baseline. This makes accurate functional mapping challenging. Marchenko-Pastur principal component analysis (MP-PCA) provides a novel strategy to separate functional MRI signal from noise without requiring user input or prior data representation. Purpose To determine whether MP-PCA denoising improves activation magnitude for task-based functional MRI language mapping in patients with brain tumors. Materials and Methods In this Health Insurance Portability and Accountability Act-compliant study, MP-PCA performance was first evaluated by using simulated functional MRI data with a known ground truth. Right-handed, left-language-dominant patients with brain tumors who successfully performed verb generation, sentence completion, and finger tapping functional MRI tasks were retrospectively identified between January 2017 and August 2018. On the group level, for each task, histograms of

Indexed as

AdolescentAdultAgedBrainBrain MappingBrain NeoplasmsChildFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedPrincipal Component AnalysisRetrospective StudiesYoung Adult

Identifiers

PMID33289611
PMCPMC7850264
OpenAlexW3112913289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.