Evidence map›Paper›PMID 33289158›Full record

ArticleJournal of leukocyte biology2020

Persons who inject drugs (PWID) retain functional NK cells, dendritic cell stimulation, and adaptive immune recall responses despite prolonged opioid use.

Costin Tomescu, Krystal Colon, Peter Smith, Mack Taylor, Livio Azzoni, David S Metzger, Luis J Montaner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Costin TomescuHIV Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Krystal ColonHIV Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Peter SmithDepartment of Psychiatry, HIV Prevention Division, The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mack TaylorDepartment of Psychiatry, HIV Prevention Division, The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Livio AzzoniHIV Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, Pennsylvania, USA.
David S MetzgerDepartment of Psychiatry, HIV Prevention Division, The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Luis J MontanerHIV Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-5799-6759
The Wistar Institute · USUniversity of Pennsylvania · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
University of Pennsylvania HIV Clinical Trials UnitUM1AI069534 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ian Frank, PABLO TEBAS · 2012 to 2026
$33.0M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Karine Dube · 2013 to 2026
$23.5M
TRAINING IN HIV PATHOGENESIST32AI007632 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman, James L. Riley · 2000 to 2026
$10.6M
Effects of mu-opiate receptor engagement on microbial translocation and residual immune activation in HIV-infected, ART suppressed opioid use disorder patents initiating medication-assisted treatmentR01DA048728 · NIDA · WISTAR INSTITUTE · PI METZGER, DAVID S, MONTANER, LUIS J · 2019 to 2023
$8.4M
Effects of Mu-opiate receptor engagement on the persistence of HIV-associated activation and viral reservoirs in individuals receiving medication assisted treatment for opioid use disorderR01DA049666 · NIDA · WISTAR INSTITUTE · PI MONTANER, LUIS J · 2019 to 2023
$4.2M
Early Innate/IgA Anti-HIV/SIV Response in Exposed UninfectedR01AI094603 · NIAID · WISTAR INSTITUTE · PI KRAISELBURD, EDMUNDO NELSON, MONTANER, LUIS J · 2011 to 2015
$3.8M
NK Cell Activation and Function in HIV-1 Exposed Uninfected IV Drug UsersR01DA028775 · NIDA · WISTAR INSTITUTE · PI MONTANER, LUIS J, SPEICHER, DAVID W. · 2010 to 2014
$3.4M
Mechanisms of Resistance in HIV-1 Exposed Sero-negative IV-drug Users: Induction of IFN-mediated Factors and S100 Proteins as Determinants of NK Cell-Mediated Clearance and Low CD4+ T Cell InfectivityR21DA040554 · NIDA · WISTAR INSTITUTE · PI TOMESCU, COSTIN · 2016 to 2017
$525k
NCI NIH HHS P30 CA010815NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI094603NIAID NIH HHS T32 AI007632NIAID NIH HHS UM1 AI069534NIAID NIH HHS UM1 AI126620NIDA NIH HHS R01 DA028775NIDA NIH HHS R01 DA048728NIDA NIH HHS R01 DA049666NIDA NIH HHS R21 DA040554NIH HHS NIDA R01DA028775NIH HHS NIDA R21DA040554NIH HHS R01AI094603NIH HHS R01 DA048728NIH HHS R01 DA049666NIH HHS T32AI007632NIH HHS UM1AI126620NIMH NIH HHS P30 MH097488
6 · The paper itself

Abstract

Previous literature suggests that acute opioid use results in the functional impairment of the immune response, thereby decreasing resistance to viral infection. Here, we assessed if innate and adaptive immune responses are compromised ex vivo in persons who inject drugs (PWID) and whether long-term injection drug use may impact host susceptibility to in vitro HIV infection. We measured the frequency, activation state, and functional profile of NK cells, dendritic cells, and CD4

Indexed as

activationHIVHIV infectionmemory responseopioidspeople who inject drugs (PWID)

Identifiers

PMID33289158
PMCPMC8244827
OpenAlexW3107523215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.