Evidence map›Paper›PMID 33289088›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2021

ADHD and risk for subsequent adverse childhood experiences: understanding the cycle of adversity.

Claudia Lugo-Candelas, Thomas Corbeil, Melanie Wall, Jonathan Posner, Hector Bird, Glorisa Canino, Prudence W Fisher, Shakira F Suglia, Cristiane S Duarte

Open access · greenAbstract read
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Parental Age and the Risk of ADHD in Offspring: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
  4. Article
  5. Article
  6. Review
  7. Grief, Relief, and Belief: A Social Media Study on Late Identification of Neurodivergence.Autism : the international journal of research and practice · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Can response to ADHD medication be predicted?European child & adolescent psychiatry · 2025
    Observational
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Claudia Lugo-CandelasNew York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-8388-9479
Thomas CorbeilNew York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.
Melanie WallNew York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.
Jonathan PosnerNew York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.
Hector BirdNew York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.
Glorisa CaninoBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, PR, USA.
Prudence W FisherNew York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.
Shakira F SugliaDepartment of Epidemiology, Emory University, Atlanta, GA, USA.
Cristiane S DuarteNew York State Psychiatric Institute, Columbia University Irving Medical Center, New York, NY, USA.
Columbia University Irving Medical Center · USEmory University · USUniversity of Puerto Rico System · PR

Funding

BREAKING THE CYCLE OF INTERGENERATIONAL DISADVANTAGE: NEURODEVELOPMENT AMONG PUERTO RICAN CHILDREN.UH3OD023328 · OD · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI CANINO, GLORISA J, DUARTE, CRISTIANE S. · 2018 to 2022
$18.3M
ANTISOCIAL BEHAVIORS IN US AND ISLAND PUERTO RICAN YOUTHR01MH056401 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE · PI BIRD, HECTOR R · 1998 to 2004
$4.5M
Substance Use/Abuse & HIV/STI Risk Behaviors in Puerto Rican Youth Growing UpR01DA033172 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DUARTE, CRISTIANE S. · 2012 to 2016
$3.2M
Maternal adversity, inflammation, and neurodevelopment: How intergenerational processes perpetuate disadvantage in a low-resource settingR01MH121070 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Cristiane S. Duarte, Andrea Parolin Jackowski · 2020 to 2026
$2.8M
A longitudinal study of prenatal maternal obesity and the fetal origins of impulsivity in Puerto Rican childrenK08MH117452 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI LUGO-CANDELAS, CLAUDIA I · 2019 to 2023
$974k
NIDA NIH HHS R01-DA033172NIH HHS UH3 OD023328NIH HHS UH3-OD023328NIMH NIH HHS K08 MH117452NIMH NIH HHS R01 MH121070NIMH NIH HHS R01-MH56401;K08-MH117452
6 · The paper itself

Abstract

backgroundChildren with adverse childhood experiences (ACEs) are more likely to develop Attention-Deficit/Hyperactivity Disorder (ADHD). The reverse relationship - ADHD predicting subsequent ACEs - is vastly understudied, although it may be of great relevance to underserved populations highly exposed to ACEs.

methodsParticipants were 5- to 15-year-olds (48% females) with (9.9%) and without ADHD (DSM-IV criteria except age of onset) in a longitudinal population-based study of Puerto Rican youth. In each wave (3 yearly assessments, W1-3), ten ACEs (covering parental loss and maladjustment and child maltreatment) were examined, plus exposure to violence. Logistic regression models examined ADHD (including subtypes) and subsequent risk for ACEs. Also considered were interactions by age, sex, number of W1 ACEs, and recruitment site.

resultsChildren with W1 ADHD were more likely to experience subsequent adversity (OR: 1.63; 95% CI: 1.12-2.37) accounting for child age, sex, public assistance, maternal education, site, disruptive behavior disorders, and W1 ACEs. Inattentive (OR: 2.00; 95% CI: 1.09-3.66), but not hyperactive/impulsive or combined ADHD, predicted future ACEs.

conclusionsADHD predicts subsequent risk for ACEs, and the inattentive presentation may confer the most risk. Inattentive presentations could pose a bigger risk given differences in symptom persistence, latency to access to treatment, and treatment duration. The present study suggests a pathway for the perpetuation of adversity, where bidirectional relationships between ADHD and ACEs may ensnare children in developmental pathways predictive of poor outcomes. Understanding the mechanism underlying this association can help the development of interventions that interrupt the cycle of adversity exposure and improve the lives of children with ADHD.

Indexed as

Adverse Childhood ExperiencesAttention Deficit Disorder with HyperactivityChild AbuseAdolescentAttention Deficit and Disruptive Behavior DisordersChildFamilyFemaleHumansMaleadverse childhood experiencesadversityAttention-deficitBoricua Youth Studyhyperactivity disorder

Identifiers

PMID33289088
PMCPMC8169708
OpenAlexW3109083401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.