Evidence map›Paper›PMID 33289044›Full record

ReviewCurrent psychiatry reports2020

Using Precision Medicine with a Neurodevelopmental Perspective to Study Inflammation and Depression.

Robert D Levitan, Cindy X W Zhang, Julia A Knight, Rayjean Hung, Jennifer Lye, Kellie Murphy, Leslie Atkinson, Alan Bocking, Stephen Lye, Stephen G Matthews

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current psychiatry reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robert D LevitanMood and Anxiety Disorders Program, Centre for Addiction and Mental Health, 100 Stokes Street, Toronto, Ontario, M6J 1H4, Canada. Robert.levitan@camh.ca.
Cindy X W ZhangDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Julia A KnightLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Rayjean HungLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Jennifer LyeLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Kellie MurphyLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Leslie AtkinsonDepartment of Psychology, Ryerson University, Toronto, Ontario, Canada.
Alan BockingLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Stephen LyeDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Stephen G MatthewsDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewTo consider various precision medicine approaches to further elucidate the relationship between inflammation and depression and to illustrate how a neurodevelopmental perspective can help in this regard. RECENT

findingsInflammation associates most strongly with phenotypes of depression that reflect illness behavior and/or metabolic dysfunction and obesity. A separate body of research has shown that maternal inflammation during pregnancy can alter brain circuitry important for mood regulation and/or reward in the developing fetus. Our research group is finding that maternal CRP levels differentially predict positive and negative affect in children assessed at age 4 years, depending on the timing of plasma sampling during pregnancy and the sex of the child. Recent authors have stressed the need to use a variety of precision medicine approaches to refine our understanding of inflammation-depression links. Adding a neurodevelopmental perspective may help to address some of the methodological challenges in this active area of study.

Indexed as

Neurodevelopmental DisordersPrenatal Exposure Delayed EffectsBrainChildChild, PreschoolDepressionFamilyFemaleHumansInflammationPrecision MedicinePregnancyDepressionDevelopmental windowInflammationNeurodevelopmentPrecision medicinesex differences

Identifiers

PMID33289044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.