ArticleNature metabolism2020
Nitrogen recycling buffers against ammonia toxicity from skeletal muscle breakdown in hibernating arctic ground squirrels.
Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Crosstalk in the cold: host-microbe interactions in insect diapause.Annals of the Entomological Society of America · 2026Review
- Active bile acid metabolism could contribute to muscle preservation in hibernating bears via the TGR5 pathway.Pflugers Archiv : European journal of physiology · 2026Article
- Article
- Incorporation of microbially salvaged urea-nitrogen into anabolic amino acids during hibernation in arctic ground squirrels.Communications biology · 2026Article
- Hibernation-Inspired Innovations in Biomedicine: Addressing Aging, Chronic Diseases, and Critical Care.Canadian journal of zoology · 2026Article
- High-Throughput Metabolomics in Transfusion Medicine.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Incorporation of microbially salvaged urea-nitrogen into anabolic amino acids during hibernation in arctic ground squirrels.bioRxiv : the preprint server for biology · 2025Article
- Increased urea nitrogen salvaging by a remodeled gut microbiota helps nonhibernating pikas maintain protein homeostasis during winter.PLoS biology · 2025Article
- Conserved lipid metabolic reprogramming confers hypoxic and aging resilience.bioRxiv : the preprint server for biology · 2025Article
- Harnessing hibernation: Unlocking nature's secrets for advances in healthy aging, critical care, and space exploration.Annals of the New York Academy of Sciences · 2025Review
- Skeletal muscle preservation in arctic ground squirrels during hibernation season.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2025Article
- Nitrogen recycling by the gut microbiome in sarcopenia.Frontiers in microbiology · 2025Article
- Microbial urea-nitrogen recycling in arctic ground squirrels: the effect of ambient temperature of hibernation.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Multiple time points of transcriptome analysis revealed altered genes involved in maintaining hibernation in the hypothalamus ofFrontiers in neuroscience · 2024Article
- The interaction between gut microbiota and hibernation in mammals.Frontiers in microbiology · 2024Review
- Unique plasma metabolite signature for adolescents with Klinefelter syndrome reveals altered fatty acid metabolism.Endocrine connections · 2023Article
- Mass spectrometry of the white adipose metabolome in a hibernating mammal reveals seasonal changes in alternate fuels and carnitine derivatives.Frontiers in physiology · 2023Article
- Nitrogen recycling via gut symbionts increases in ground squirrels over the hibernation season.Science (New York, N.Y.) · 2022Article
- High-Throughput Metabolomics Platform for the Rapid Data-Driven Development of Novel Additive Solutions for Blood Storage.Frontiers in physiology · 2022Article
- Muscles in Winter: The Epigenetics of Metabolic Arrest.Epigenomes · 2021Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Hibernation is a state of extraordinary metabolic plasticity. The pathways of amino acid metabolism as they relate to nitrogen homeostasis in hibernating mammals in vivo are unknown. Here we show, using pulse isotopic tracing, evidence of increased myofibrillar (skeletal muscle) protein breakdown and suppressed whole-body production of metabolites in vivo throughout deep torpor. As whole-body production of metabolites is suppressed, amino acids with nitrogenous side chains accumulate during torpor, while urea cycle intermediates do not. Using
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.