Evidence map›Paper›PMID 33288948›Full record

ArticleNature nanotechnology2021

Micelle-enabled self-assembly of porous and monolithic carbon membranes for bioelectronic interfaces.

Yin Fang, Aleksander Prominski, Menahem Y Rotenberg, Lingyuan Meng, Héctor Acarón Ledesma, Yingying Lv, Jiping Yue, Erik Schaumann, Junyoung Jeong, Naomi Yamamoto and 4 more

Open access · greenAbstract read
In one paragraph

Article in Nature nanotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
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  3. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  19. Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications.Langmuir : the ACS journal of surfaces and colloids · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Yin Fang *Department of Chemistry, University of Chicago, Chicago, IL, USA. yinfang@nano-theranostic.com.ORCID http://orcid.org/0000-0002-7068-1628
Aleksander Prominski *Department of Chemistry, University of Chicago, Chicago, IL, USA.
Menahem Y Rotenberg *The James Franck Institute, University of Chicago, Chicago, IL, USA.
Lingyuan Meng *Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1690-586X
Héctor Acarón Ledesma *The Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL, USA.
Yingying LvThe James Franck Institute, University of Chicago, Chicago, IL, USA.
Jiping YueDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Erik SchaumannDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Junyoung JeongDepartment of Computer Science, University of Chicago, Chicago, IL, USA.
Naomi YamamotoDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-0641-6547
Yuanwen JiangDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-2056-2639
Benayahu ElbazThe Division of Multiple Sclerosis and Neuroimmunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Wei WeiDepartment of Neurobiology, University of Chicago, Chicago, IL, USA.
Bozhi TianDepartment of Chemistry, University of Chicago, Chicago, IL, USA. btian@uchicago.edu.ORCID http://orcid.org/0000-0003-0593-0023
University of Chicago · USSchool of the Art Institute of Chicago · USNorthwestern University · US

Funding

Silicon-based Injectable Micro-gels for Non-genetic and Wireless Modulation of Neurons, Cardiomyocytes and Neuromuscular SystemDP2NS101488 · NINDS · UNIVERSITY OF CHICAGO · PI TIAN, BOZHI · 2016 to 2016
$2.4M
NINDS NIH HHS DP2 NS101488
6 · The paper itself

Abstract

Real-world bioelectronics applications, including drug delivery systems, biosensing and electrical modulation of tissues and organs, largely require biointerfaces at the macroscopic level. However, traditional macroscale bioelectronic electrodes usually exhibit invasive or power-inefficient architectures, inability to form uniform and subcellular interfaces, or faradaic reactions at electrode surfaces. Here, we develop a micelle-enabled self-assembly approach for a binder-free and carbon-based monolithic device, aimed at large-scale bioelectronic interfaces. The device incorporates a multi-scale porous material architecture, an interdigitated microelectrode layout and a supercapacitor-like performance. In cell training processes, we use the device to modulate the contraction rate of primary cardiomyocytes at the subcellular level to target frequency in vitro. We also achieve capacitive control of the electrophysiology in isolated hearts, retinal tissues and sciatic nerves, as well as bioelectronic cardiac sensing. Our results support the exploration of device platforms already used in energy research to identify new opportunities in bioelectronics.

Indexed as

Membranes, ArtificialMicellesBiocompatible MaterialsBiosensing TechniquesCarbonElectrodesEquipment DesignNanostructuresPorosityBiocompatible MaterialsCarbonMembranes, ArtificialMicelles

Identifiers

PMID33288948
PMCPMC8801202
OpenAlexW3111815842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.