Evidence map›Paper›PMID 33288910›Full record

ArticleNature neuroscience2021

GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors.

Sara Mederos, Cristina Sánchez-Puelles, Julio Esparza, Manuel Valero, Alexey Ponomarenko, Gertrudis Perea

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 165 citations in OpenAlex.

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  13. GABA-independent activation of GABANature communications · 2025
    Article
  14. Astrocytic CaNature neuroscience · 2025
    Article
  15. Science advances · 2025
    Article
  16. Astrocytes as Active Participants in Memory.Journal of neurochemistry · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Sara MederosInstituto Cajal (CSIC), Madrid, Spain.ORCID http://orcid.org/0000-0003-0960-9974
Cristina Sánchez-PuellesInstituto Cajal (CSIC), Madrid, Spain.
Julio EsparzaInstituto Cajal (CSIC), Madrid, Spain.ORCID http://orcid.org/0000-0001-6397-3094
Manuel ValeroNYU Neuroscience Institute, New York University Langone Medical Center, New York, NY, USA.
Alexey PonomarenkoInstitute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0002-5185-0107
Gertrudis PereaInstituto Cajal (CSIC), Madrid, Spain. gperea@cajal.csic.es.ORCID http://orcid.org/0000-0001-5924-9175
Instituto Cajal · ESFriedrich-Alexander-Universität Erlangen-Nürnberg · DENYU Langone Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to stable performance of complex behaviors. Here, we found that genetic ablation of GABA

Indexed as

GoalsAnimalsAstrocytesCognitionDecision MakingGABAergic Neuronsgamma-Aminobutyric AcidGamma RhythmInterneuronsMelanopsinMemory, Short-TermMiceMice, Inbred C57BLMice, KnockoutOptogeneticsPrefrontal Cortexgamma-Aminobutyric AcidMelanopsinReceptors, GABA-BRod Opsins

Identifiers

PMID33288910
OpenAlexW3111289092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.