ArticleScientific reports2020
Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Restoring RCAN1 dosage mitigates sleep and EEG abnormalities in a Down syndrome model.Neurobiology of disease · 2026Article
- An automated deep learning-based pipeline for 3D characterisation of the murine upper airway from micro-CT.Frontiers in medical technology · 2026Article
- Sleep Fragmentation in TcMAC21 Mouse Model of Down Syndrome.Nature and science of sleep · 2025Article
- Is the mouse nose a miniature version of a rat nose? A computational comparative study.Computer methods and programs in biomedicine · 2024Article
- Sleep-Disordered Breathing and Associated Comorbidities among Preschool-Aged Children with Down Syndrome.Children (Basel, Switzerland) · 2024Article
- Ultrasonic vocalization phenotypes in the Ts65Dn and Dp(16)1Yey mouse models of Down syndrome.Physiology & behavior · 2023Article
- Photobehaviours guided by simple photoreceptor systems.Animal cognition · 2023Review
- Article
- Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome.Children (Basel, Switzerland) · 2021Review
- Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes.Disease models & mechanisms · 2021Article
- Altered responses of end-expiratory lung volume and upper airway patency to body posture in diet-induced obese mice.Physiological reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
A high prevalence of obstructive sleep apnea (OSA) has been reported in Down syndrome (DS) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of OSA. We hypothesized that DS mice recapitulate craniofacial abnormalities and upper airway obstruction of human DS and can serve as an experimental platform for OSA research. This study, thus, aimed to quantitatively characterize the upper airway as well as craniofacial abnormalities in Dp(16)1Yey (Dp16) mice. Dp16 mice demonstrated craniofacial hypoplasia, especially in the ventral part of the skull and the mandible, and rostrally positioned hyoid. These changes were accompanied with a shorter length and smaller cross-sectional area of the upper airway, resulting in a significantly reduced upper airway volume in Dp16 mice. Our non-invasive approach, a combination of computational fluid dynamics and high-resolution micro-CT imaging, revealed a higher negative pressure inside the airway of Dp16 mice compared to wild-type littermates, showing the potential risk of upper airway collapse. Our study indicated that Dp16 mice can be a useful model to examine the pathophysiology of increased upper airway collapsibility of DS and to evaluate the efficacy of therapeutic interventions for breathing and sleep anomalies.
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