ArticleNature communications2020
Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Human vagus nerve fascicular anatomy and its implications for targeted cardiac stimulation: a microCT segmentation and histological pilot anatomical study.Frontiers in neuroscience · 2026Article
- Emergent technologies in clinical neurophysiology to study the neuromuscular system: IFCN handbook chapter.Clinical neurophysiology practice · 2026Review
- Temporal interference stimulation of peripheral nerves induces functionally diverse limb movements revealed by automated pose estimation and unsupervised behavioral analysis.Journal of neuroengineering and rehabilitation · 2025Article
- Scaling of vagus nerve stimulation parameters does not achieve equivalent nerve responses across species.Bioelectronic medicine · 2025Article
- Precise control of tibial nerve stimulation for bladder regulation via evoked compound action potential feedback mechanisms.Nature communications · 2025Article
- A wearable triboelectric impedance tomography system for noninvasive and dynamic imaging of biological tissues.Science advances · 2024Article
- NRV: An open framework for in silico evaluation of peripheral nerve electrical stimulation strategies.PLoS computational biology · 2024Article
- Using neural biomarkers to personalize dosing of vagus nerve stimulation.Bioelectronic medicine · 2024Article
- NRV: An open framework forbioRxiv : the preprint server for biology · 2024Article
- Organotopic organization of the porcine mid-cervical vagus nerve.Frontiers in neuroscience · 2023Article
- A combined cuff electrode array for organ-specific selective stimulation of vagus nerve enabled by Electrical Impedance Tomography.Frontiers in medical technology · 2023Article
- A method to establish functional vagus nerve topography from electro-neurographic spontaneous activity.Patterns (New York, N.Y.) · 2022Article
- Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems.Neuron · 2022Article
- Intraneural Topography of Rat Sciatic Axons: Implications for Polyethylene Glycol Fusion Peripheral Nerve Repair.Frontiers in cellular neuroscience · 2022Article
- Advances of deep learning in electrical impedance tomography image reconstruction.Frontiers in bioengineering and biotechnology · 2022Review
- Mapping the functional anatomy and topography of the cardiac autonomic innervation for selective cardiac neuromodulation using MicroCT.Frontiers in cell and developmental biology · 2022Article
- Fascicle localisation within peripheral nerves through evoked activity recordings: A comparison between electrical impedance tomography and multi-electrode arrays.Journal of neuroscience methods · 2021Article
- Interfacial polarization of in vivo rat sciatic nerve with crush injury studied via broadband dielectric spectroscopy.PloS one · 2021Article
- Selective Vagus Nerve Stimulation as a Therapeutic Approach for the Treatment of ARDS: A Rationale for Neuro-Immunomodulation in COVID-19 Disease.Frontiers in neuroscience · 2021Review
- Imaging fascicular organization of rat sciatic nerves with fast neural electrical impedance tomography.Nature communications · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Imaging compound action potentials (CAPs) in peripheral nerves could help avoid side effects in neuromodulation by selective stimulation of identified fascicles. Existing methods have low resolution, limited imaging depth, or are invasive. Fast neural electrical impedance tomography (EIT) allows fascicular CAP imaging with a resolution of <200 µm, <1 ms using a non-penetrating flexible nerve cuff electrode array. Here, we validate EIT imaging in rat sciatic nerve by comparison to micro-computed tomography (microCT) and histology with fluorescent dextran tracers. With EIT, there are reproducible localized changes in tissue impedance in response to stimulation of individual fascicles (tibial, peroneal and sural). The reconstructed EIT images correspond to microCT scans and histology, with significant separation between the fascicles (p < 0.01). The mean fascicle position is identified with an accuracy of 6% of nerve diameter. This suggests fast neural EIT can reliably image the functional fascicular anatomy of the nerves and so aid selective neuromodulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.