ArticleNature communications2020
Pandemic Vibrio cholerae shuts down site-specific recombination to retain an interbacterial defence mechanism.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Serlogical, virulence, and molecular characterization of clinical and seafoodMicrobiology spectrum · 2026Article
- Temperate phages enhance bacterial host fitness via RNA-guided flagellar remodelling.Nature microbiology · 2026Article
- The type VI secretion system and associated effector proteins.Nature reviews. Microbiology · 2026Review
- Exploring Mobile Genetic Elements in Vibrio cholerae.Genome biology and evolution · 2025Article
- Review of the Presence and Phage-Mediated Transfer of ARGs in Biofilms.Microorganisms · 2025Review
- Recent Discovery of Diverse Prophages Located in Genomes ofFoods (Basel, Switzerland) · 2025Review
- Virulent properties and genomic diversity ofMicrobiology spectrum · 2024Article
- Pesticin-Like Effector VgrG3Microbiology spectrum · 2023Article
- PandemicLife science alliance · 2023Article
- Advances in cholera research: from molecular biology to public health initiatives.Frontiers in microbiology · 2023Review
- Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy.Advances in experimental medicine and biology · 2023Article
- Review
- Type VI Secretion Systems: Environmental and Intra-host Competition of Vibrio cholerae.Advances in experimental medicine and biology · 2023Article
- Getting ahead of the competition.Nature reviews. Microbiology · 2021Article
- A New Contact Killing Toxin Permeabilizes Cells and Belongs to a Broadly Distributed Protein Family.mSphere · 2021Article
- Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clustering.PLoS genetics · 2021Article
- Modular Molecular Weaponry Plays a Key Role in Competition Within an EnvironmentalFrontiers in microbiology · 2021Article
- Bioinformatic Analysis of theFrontiers in microbiology · 2021Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Vibrio cholerae is an aquatic microbe that can be divided into three subtypes: harmless environmental strains, localised pathogenic strains, and pandemic strains causing global cholera outbreaks. Each type has a contact-dependent type VI secretion system (T6SS) that kills neighbouring competitors by translocating unique toxic effector proteins. Pandemic isolates possess identical effectors, indicating that T6SS effectors may affect pandemicity. Here, we show that one of the T6SS gene clusters (Aux3) exists in two states: a mobile, prophage-like element in a small subset of environmental strains, and a truncated Aux3 unique to and conserved in pandemic isolates. Environmental Aux3 can be readily excised from and integrated into the genome via site-specific recombination, whereas pandemic Aux3 recombination is reduced. Our data suggest that environmental Aux3 acquisition conferred increased competitive fitness to pre-pandemic V. cholerae, leading to grounding of the element in the chromosome and propagation throughout the pandemic clade.
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