Evidence map›Paper›PMID 33288739›Full record

ArticleAging2020

Identification of "regulation of RhoA activity panel" as a prognostic and predictive biomarker for gastric cancer.

Wenwen Huang, Songhui Zhao, Cheng Zhang, Zhongwu Li, Sai Ge, Baofeng Lian, Hui Feng, Kai Wang, Ruihua Xu, Jiafu Ji and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Wenwen HuangDepartment of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China.
Songhui ZhaoOrigiMed Inc., Shanghai 201112, China.
Cheng ZhangDepartment of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China.
Zhongwu LiDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China.
Sai GeDepartment of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China.
Baofeng LianOrigiMed Inc., Shanghai 201112, China.
Hui FengShanghai Junshi Biosciences Co., Ltd, Shanghai 201203, China.
Kai WangOrigiMed Inc., Shanghai 201112, China.
Ruihua XuState Key Laboratory of Oncology in South China, Department of Medical Oncology, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Jiafu JiDepartment of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China.
Jing GaoNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China.
Weiwei ShiOrigiMed Inc., Shanghai 201112, China.
Lin ShenDepartment of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China.
Peking University · CNPeking University Cancer Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNSun Yat-sen University · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RhoA is a member of the RHO family GTPases and is associated with essential functions in gastric cancer. In this study, we identified a gastric cancer biomarker, termed the "regulation of RhoA activity panel" (RRAP). Patients with gastric cancer from The Cancer Genome Atlas database were divided into training (N=160) and validation (N=155) cohorts. A cohort of 109 Chinese gastric cancer patients was utilized as an independent validation. Patients with mutated RRAP showed significantly better overall survival than patients with wild type RRAP. We also analyzed the association between RRAP and the migration capacity, immune-related signatures, and the tumor microenvironment. RRAP-mutant tumors had a significantly lower degree of lymph node metastasis and lower activities of migration-related pathways. These tumors also showed significantly increased immune cell infiltration and cytotoxic activity. Furthermore, two independent patient cohorts who received immune checkpoint blockade therapy were assessed for RRAP mutant status. As expected, for both immunotherapy cohorts, higher response rates to immune checkpoint blockade therapy were observed in patients with RRAP-mutant tumors than in patients with wild type RRAP tumors. Overall, this study indicates that the RRAP gene set is a potential biomarker for gastric cancer prognosis and therapeutic selection.

Indexed as

AdultAgedAged, 80 and overCarcinomacdc42 GTP-Binding ProteinCell MovementCohort StudiesCyclin-Dependent Kinase Inhibitor p27FemaleGene Expression Regulation, NeoplasticGlycine Plasma Membrane Transport ProteinsGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsHumansLymphatic MetastasisMaleBCR protein, humancdc42 GTP-Binding ProteinCDC42 protein, humanCDKN1B protein, humanCyclin-Dependent Kinase Inhibitor p27DLEC1 protein, humanFARP1 protein, humanGlycine Plasma Membrane Transport ProteinsGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsNET1 protein, humanNGEF protein, humanOBSCN protein, humanOncogene ProteinsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-bcrProto-Oncogene Proteins c-vavrhoA GTP-Binding ProteinRHOA protein, humanRho Guanine Nucleotide Exchange FactorsSLC6A5 protein, humanTumor Suppressor Proteinsgastric cancerprognosis and predictive biomarkerregulation of RhoA activitytumor microenvironmenttumor migration

Identifiers

PMID33288739
PMCPMC7835016
OpenAlexW3109228923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.