Evidence map›Paper›PMID 33288654›Full record

ReviewCold Spring Harbor perspectives in medicine2021

Computational Tools for Causal Inference in Genetics.

Tom G Richardson, Jie Zheng, Tom R Gaunt

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Causal Inference with Genetic Data: Past, Present, and Future.Cold Spring Harbor perspectives in medicine · 2022
    Review
  2. Human Genomics and Drug Development.Cold Spring Harbor perspectives in medicine · 2022
    Review
  3. Mendelian Randomization: Concepts and Scope.Cold Spring Harbor perspectives in medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tom G RichardsonMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, United Kingdom.
Jie ZhengMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, United Kingdom.
Tom R GauntMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, United Kingdom.

Funding

Department of HealthMedical Research Council MC_UU_00011/4
6 · The paper itself

Abstract

The advent of large-scale, phenotypically rich, and readily accessible data provides an unprecedented opportunity for epidemiologists, statistical geneticists, bioinformaticians, and also behavioral and social scientists to investigate the causes and consequences of disease. Computational tools and resources are an integral component of such endeavors, which will become increasingly important as these data continue to grow exponentially. In this review, we have provided an overview of computational software and databases that have been developed to assist with analyses in causal inference. This includes online tools that can be used to help generate hypotheses, publicly accessible resources that store summary-level information for millions of genetic markers, and computational approaches that can be used to leverage this wealth of data to study causal relationships.

Indexed as

Databases, FactualGenetic Predisposition to DiseaseSoftwareComputational BiologyHumans

Identifiers

PMID33288654
PMCPMC8168525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.