Evidence map›Paper›PMID 33288625›Full record

ArticleJournal of bacteriology2021

Functional Characterization of the γ-Aminobutyric Acid Transporter from Mycobacterium smegmatis MC

Ana Pavić, Yurui Ji, Agnese Serafini, Acely Garza-Garcia, Martin J McPhillie, Alexandra O M Holmes, Luiz Pedro Sório de Carvalho, Yingying Wang, Mark Bartlam, Adrian Goldman and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. eLife · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Ana Pavić *Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
Yurui Ji *Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
Agnese SerafiniMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.
Acely Garza-GarciaMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.
Martin J McPhillieSchool of Chemistry, Faculty of Engineering & Physical Sciences, University of Leeds, Leeds, United Kingdom.
Alexandra O M HolmesAstbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
Luiz Pedro Sório de CarvalhoMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London, United Kingdom.
Yingying WangCollege of Environmental Sciences & Engineering, Nankai University, Tianjin, China.
Mark BartlamCollege of Life Sciences, Nankai University, Tianjin, China bartlam@nankai.edu.cn A.Goldman@leeds.ac.uk v.l.postis@leedsbeckett.ac.uk.ORCID 0000-0001-5173-5080
Adrian GoldmanAstbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom bartlam@nankai.edu.cn A.Goldman@leeds.ac.uk v.l.postis@leedsbeckett.ac.uk.ORCID 0000-0001-8032-9700
Vincent L G PostisAstbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom bartlam@nankai.edu.cn A.Goldman@leeds.ac.uk v.l.postis@leedsbeckett.ac.uk.
University of Leeds · GBThe Francis Crick Institute · GBNankai University · CN

Funding

Biotechnology and Biological Sciences Research Council M021610Wellcome TrustWellcome Trust FC0010060
6 · The paper itself

Abstract

Characterizing the mycobacterial transporters involved in the uptake and/or catabolism of host-derived nutrients required by mycobacteria may identify novel drug targets against tuberculosis. Here, we identify and characterize a member of the amino acid-polyamine-organocation superfamily, a potential γ-aminobutyric acid (GABA) transport protein, GabP, from

Indexed as

Bacterial ProteinsBiological TransportEscherichia coliEscherichia coli ProteinsGABA Plasma Membrane Transport Proteinsgamma-Aminobutyric AcidGene Expression Regulation, BacterialMetabolomicsMolecular Docking SimulationMycobacterium smegmatisOrganic Anion TransportersPhylogenySodiumBacterial ProteinsEscherichia coli ProteinsGABA Plasma Membrane Transport ProteinsgabP protein, E coligamma-Aminobutyric AcidOrganic Anion TransportersSodiumGABAmembrane biologymycobacteriatransporter

Identifiers

PMID33288625
PMCPMC7847548
OpenAlexW3110496688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.