Evidence map›Paper›PMID 33288542›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Cutting Edge: NOX2 NADPH Oxidase Controls Infection by an Intracellular Bacterial Pathogen through Limiting the Type 1 IFN Response.

Jorge David Rojas Márquez, Taoyingnan Li, Adam R R McCluggage, Joel M J Tan, Aleixo Muise, Darren E Higgins, John H Brumell

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Journal of animal science and technology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jorge David Rojas MárquezCell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.ORCID 0000-0001-6385-030X
Taoyingnan LiCell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.ORCID 0000-0003-0548-9442
Adam R R McCluggageCell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Joel M J TanCell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.ORCID 0000-0002-6051-3786
Aleixo MuiseCell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.ORCID 0000-0001-9624-3346
Darren E HigginsDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115 dhiggins@hms.harvard.edu john.brumell@sickkids.ca.ORCID 0000-0003-0562-1300
John H BrumellCell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada; dhiggins@hms.harvard.edu john.brumell@sickkids.ca.ORCID 0000-0002-5802-7789
University of Toronto · CAHospital for Sick Children · CAHarvard University · US

Funding

COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8M
Mechanisms regulating vimentin-dependent invasion of the brain by Listeria monocytogenesR01AI146102 · NIAID · HARVARD MEDICAL SCHOOL · PI BRUMELL, JOHN HUNTER, HIGGINS, DARREN E · 2019 to 2022
$1.6M
CIHR FDN154329CIHR THC135233NIAID NIH HHS R01 AI146102NIDDK NIH HHS RC2 DK118640
6 · The paper itself

Abstract

The NOX2 NADPH oxidase (NOX2) produces reactive oxygen species to kill phagosome-confined bacteria. However, we previously showed that

Indexed as

AnimalsCell MovementCells, CulturedInflammationInterferon Type IInterleukin-10LeukocytesListeria monocytogenesListeriosisMacrophagesMiceMice, Inbred C57BLMice, KnockoutNADPH Oxidase 2ThioredoxinsInterferon Type IInterleukin-10NADPH Oxidase 2Thioredoxins

Identifiers

PMID33288542
PMCPMC7776882
OpenAlexW3112458997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.