ArticleMedical hypotheses2021
Can preprocedural mouthrinses reduce SARS-CoV-2 load in dental aerosols?
Article in Medical hypotheses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06272019 (Alternative Application Methods of Pre-procedural Povidone Iodine Mouthrinse), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Alternative Application Methods of Pre-procedural Povidone Iodine Mouthrinse
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental healthcare providers.The Cochrane database of systematic reviews · 2022Pooled it
- Could mouth rinses be an adjuvant in the treatment of SARS-CoV-2 patients? An appraisal with a systematic review.International journal of dental hygiene · 2022Pooled it
- Comparison of gargling and swabbing methods for delivering pre-procedural povidone-iodine mouthrinse: a randomised crossover trial.BMC oral health · 2026Trial
- Oral mouthwashes for asymptomatic to mildly symptomatic adults with COVID-19 and salivary viral load: a randomized, placebo-controlled, open-label clinical trial.BMC oral health · 2024Trial
- Effect of Antiseptic Mouthwash/Gargling Solutions on SARS-CoV-2 Viral Load: A Randomized Clinical Trial.medRxiv : the preprint server for health sciences · 2026Article
- Influence of different types of mouthwashes on force decay of elastomeric chain recommended in SARS-COV-2 pandemic.Journal of orthodontic science · 2024Article
- Efficacy of different mouthwashes against COVID-19: A systematic review and network meta-analysis.The Japanese dental science review · 2023Review
- Antimicrobial Mouthwashes: An Overview of Mechanisms-What Do We Still Need to Know?International dental journal · 2023Review
- HOCl Rapidly Kills Corona, Flu, and Herpes to Prevent Aerosol Spread.Journal of dental research · 2023Article
- Repurposing povidone-iodine to reduce the risk of SARS-CoV-2 infection and transmission: a narrative review.Annals of medicine · 2022Review
- Comparison of Chlorhexidine and Hydrogen Peroxide as Preprocedural Mouthrinse during Ultrasonic Scaling: A Triple-Blinded Randomized Controlled Clinical Trial.Journal of pharmacy & bioallied sciences · 2022Article
- Mouthrinses and SARS-CoV-2 viral load in saliva: a living systematic review.Evidence-based dentistry · 2022Review
- The effectiveness of mouthwash against SARS-CoV-2 infection: A review of scientific and clinical evidence.Journal of the Formosan Medical Association = Taiwan yi zhi · 2022Review
- The New Normalcy in Dentistry after the COVID-19 Pandemic: An Italian Cross-Sectional Survey.Dentistry journal · 2021Article
- COVID-19 in Dental Settings: Novel Risk Assessment Approach.International journal of environmental research and public health · 2021Review
- Salivary SARS-CoV-2 load reduction with mouthwash use: A randomized pilot clinical trial.Heliyon · 2021Article
- Optimizing Safe Dental Practice During the COVID-19 Pandemic: Recommendations Based on a Guide Developed for Dental Practices in China.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental professionals work closely with patients and present an increased risk of person-to-person transmission of SARS-CoV-2. Moreover, the use of ultrasonic scalers, air-water syringes, and slow and high-speed handpieces, which are common in the dental office, generate spatter and aerosol. The use of preprocedural mouthrinses has been proposed to reduce the viral load in saliva and oropharyngeal tissues, thus decreasing viral load in dental aerosol. Although some mouthrinses demonstrates an antiviral effect, there is limited evidence about the clinical efficacy of any mouthrinse in the reduction of SARS-CoV-2 in the dental aerosol. We hypothesized that mouthrinses may reduce SARS-CoV-2 viral load in the oropharynx and its fluids reducing viral load in dental aerosol. The potential use of mouthrinses is discussed, along with proposal of in vitro and clinical studies, in order to evaluate this hypothesis. If this hypothesis holds true, dental professionals and patients may benefit from the routine use of preprocedural mouthrinses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.