ArticleeLife2020
Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism.
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Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
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- Centriolar satellites regulatebioRxiv : the preprint server for biology · 2026Article
- Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neutrophil and macrophage zonation in liver disease: from spatiotemporal dynamics to advanced computational analysis.Frontiers in immunology · 2026Review
- Circadian metabolism in myeloid cells.Life metabolism · 2025Review
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- Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy.Frontiers in endocrinology · 2025Review
- The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk.Nature communications · 2024Article
- The Biological Clock of Liver Metabolism in Metabolic Dysfunction-Associated Steatohepatitis Progression to Hepatocellular Carcinoma.Biomedicines · 2024Review
- Exploring transcriptomic databases: unraveling circadian gene disruptions in lower grade glioma.Scientific reports · 2024Article
- Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.The Journal of clinical investigation · 2024Article
- Lack of p38 activation in T cells increases IL-35 and protects against obesity by promoting thermogenesis.EMBO reports · 2024Article
- Crosstalk between circadian clocks and pathogen niche.PLoS pathogens · 2024Review
- Higher Seasonal Variation of Systemic Inflammation in Bipolar Disorder.International journal of molecular sciences · 2024Article
- Beyond host defense and tissue injury: the emerging role of neutrophils in tissue repair.American journal of physiology. Cell physiology · 2024Review
- Article
- Associations between systemic inflammation indicators and nonalcoholic fatty liver disease: evidence from a prospective study.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
26 authors at 4 institutions in 2 countries.
María Crespo *Centro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.ORCID 0000-0003-3666-3415
Barbara Gonzalez-Teran *Centro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.ORCID 0000-0002-4336-8644
Ivana NikolicCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Alfonso MoraCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.ORCID 0000-0002-6397-4836
Cintia FolgueiraCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Elena RodríguezCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Luis Leiva-VegaCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Aránzazu Pintor-ChocanoCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Macarena Fernández-ChacónCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Irene Ruiz-GarridoCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Beatriz CicuéndezCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Antonia Tomás-LobaCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Noelia A-GonzalezCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.ORCID 0000-0003-0533-5216
Ainoa Caballero-MolanoCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Daniel BeiroaCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain.
Lourdes Hernández-CosidoDepartment of General Surgery, University Hospital of Salamanca-IBSAL, Department of Surgery, University of Salamanca, Salamanca, Spain.
Jorge L TorresDepartment of Internal Medicine, University Hospital of Salamanca-IBSAL, Department of Medicine, University of Salamanca, Salamanca, Spain.
Norman J KennedyHoward Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, United States.
Roger J DavisHoward Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, United States.ORCID 0000-0002-0130-1652
Rui BeneditoCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Miguel MarcosDepartment of Internal Medicine, University Hospital of Salamanca-IBSAL, Department of Medicine, University of Salamanca, Salamanca, Spain.
Ruben NogueirasCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain.
Andrés HidalgoCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Nuria MatesanzCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.
Magdalena Leiva *Centro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.ORCID 0000-0001-7735-2459
Guadalupe SabioCentro Nacional de Investigaciones Cardiovasculares Carlos (CNIC), Madrid, Spain.ORCID 0000-0002-2822-0625
Spanish National Centre for Cardiovascular Research · ESUniversidad de Salamanca · ESHoward Hughes Medical Institute · USUniversidade de Santiago de Compostela · ES
Funding
Metabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6MPromotion of fatty liver disease by the ASK1 pathwayR01DK121545 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2019 to 2021
$1.6MDRUGS OF ABUSE AND BRAIN STIMULATION REWARDR01DA002326 · NIDA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KORNETSKY, CONAN · 1985 to 2000
$65kFAMILY THERAPY VS TRADITIONAL THERAPY FOR DRUG ABUSERSR01DA003733 · NIDA · TEXAS TECH UNIVERSITY · PI JOANNING, HARVEY · 1985 to 1988
–CNIC IPP FP7 Marie Curie Programme PCOFUND-2012-600396Comunidad de Madrid B2017/BMD-3733Comunidad de Madrid S2010/BMD-2326European Commission ERC260464FPI Severo Ochoa- CNIC SVP-2013-067639Fundación BBVA IN[17]_BBM_BAS_0066Fundación Científica Asociación Española Contra el Cáncer INVES20026LEIV PROYE19047SABIInstituto de Salud Carlos III PI16/01548Juan de la Cierva JCI-2011-11623Juan de la Cierva JDC-2018-Incorporación MIN/JDC1802Junta de Castilla y León GRS 1356/A/16Junta de Castilla y León GRS1362/A/16Junta de Castilla y León GRS 1587/A/17Junta de Castilla y León INT/M/17/17Ministerio de Ciencia e Innovación PID2019-104399RB-I00Ministerio de Economía y Competitividad BES-2017-079711Ministerio de Economía y Competitividad EUIN2017-85875Ministerio de Economía y Competitividad SAF2014-61233-JINMinisterio de Economía y Competitividad SAF2015-74112-JINMinisterio de Economía y Competitividad SAF2016-79126-RNIDDK NIH HHS R01 DK107220NIDDK NIH HHS R01 DK121545NIH HHS DK R01 DK107220Sara Borrell CD19/00078
Abstract
Liver metabolism follows diurnal fluctuations through the modulation of molecular clock genes. Disruption of this molecular clock can result in metabolic disease but its potential regulation by immune cells remains unexplored. Here, we demonstrated that in steady state, neutrophils infiltrated the mouse liver following a circadian pattern and regulated hepatocyte clock-genes by neutrophil elastase (NE) secretion. NE signals through c-Jun NH2-terminal kinase (JNK) inhibiting fibroblast growth factor 21 (FGF21) and activating
Indexed as
AnimalsCells, CulturedCircadian RhythmCLOCK ProteinsFibroblast Growth FactorsGene Expression RegulationHepatocytesHumansInflammationMAP Kinase Kinase 4MiceMice, TransgenicNeutropeniaNeutrophilsCLOCK Proteinsfibroblast growth factor 21Fibroblast Growth FactorsMAP Kinase Kinase 4cell biologycircadian rhythmimmunologyinflammationJNKmouseneutrophil elastasesteatosis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.