ArticleMolecular autism2020
Alpha connectivity and inhibitory control in adults with autism spectrum disorder.
Article in Molecular autism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
- Volitional modification of brain activity in adolescents with Autism Spectrum Disorder: A Bayesian analysis of Slow Cortical Potential neurofeedback.NeuroImage. Clinical · 2021Trial
- Response Inhibition in Autistic Adults: A Functional Near-Infrared Spectroscopy Study in Virtual Reality.Brain and behavior · 2026Article
- Theta and alpha connectivity in children with autism spectrum disorder.Brain communications · 2025Article
- Effect of Infra Low Frequency (ILF) neurofeedback training on EEG in children with autism spectrum disorders.Pakistan journal of medical sciences · 2024Article
- EEG Correlates of Cognitive Functions in a Child with ASD and White Matter Signal Abnormalities: A Case Report with Two-and-a-Half-Year Follow-Up.Diagnostics (Basel, Switzerland) · 2023Article
- Linear and Non-linear Analyses of EEG in a Group of ASD Children During Resting State Condition.Brain topography · 2023Article
- Very preterm brain at rest: longitudinal social-cognitive network connectivity during childhood.Social cognitive and affective neuroscience · 2022Article
- Training and Transfer Effects of Combining Inhibitory Control Training With Transcutaneous Vagus Nerve Stimulation in Healthy Adults.Frontiers in psychology · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIndividuals with autism spectrum disorder (ASD) often report difficulties with inhibition in everyday life. During inhibition tasks, adults with ASD show reduced activation of and connectivity between brain areas implicated in inhibition, suggesting impairments in inhibitory control at the neural level. Our study further investigated these differences by using magnetoencephalography (MEG) to examine the frequency band(s) in which functional connectivity underlying response inhibition occurs, as brain functions are frequency specific, and whether connectivity in certain frequency bands differs between adults with and without ASD.
methodsWe analysed MEG data from 40 adults with ASD (27 males; 26.94 ± 6.08 years old) and 39 control adults (27 males; 27.29 ± 5.94 years old) who performed a Go/No-go task. The task involved two blocks with different proportions of No-go trials: Inhibition (25% No-go) and Vigilance (75% No-go). We compared whole-brain connectivity in the two groups during correct No-go trials in the Inhibition vs. Vigilance blocks between 0 and 400 ms.
resultsDespite comparable performance on the Go/No-go task, adults with ASD showed reduced connectivity compared to controls in the alpha band (8-14 Hz) in a network with a main hub in the right inferior frontal gyrus. Decreased connectivity in this network predicted more self-reported difficulties on a measure of inhibition in everyday life. LIMITATIONS: Measures of everyday inhibitory control were not available for all participants, so this relationship between reduced network connectivity and inhibitory control abilities may not be necessarily representative of all adults with ASD or the larger ASD population. Further research with independent samples of adults with ASD, including those with a wider range of cognitive abilities, would be valuable.
conclusionsOur findings demonstrate reduced functional brain connectivity during response inhibition in adults with ASD. As alpha-band synchrony has been linked to top-down control mechanisms, we propose that the lack of alpha synchrony observed in our ASD group may reflect difficulties in suppressing task-irrelevant information, interfering with inhibition in real-life situations.
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