Evidence map›Paper›PMID 33287885›Full record

ArticleJournal of medical case reports2020

Use of low-molecular-weight heparin in severe paraquat poisoning: a case report.

Maria A Montoya-Giraldo, Luisa F Díaz, Ubier E Gómez, Juliana Quintero, Andres F Zuluaga

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of medical case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Lionfish envenomation case treated in an emergency unit in ColombiaBiomedica : revista del Instituto Nacional de Salud · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maria A Montoya-GiraldoCIEMTO [Drug and Poison Research and Information Center], Calle 64 # 51-31, Laboratorio Integrado de Medicina Especializada (LIME), IPS Universitaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Antioquia, Colombia.ORCID http://orcid.org/0000-0002-3756-0074
Luisa F DíazCIEMTO [Drug and Poison Research and Information Center], Calle 64 # 51-31, Laboratorio Integrado de Medicina Especializada (LIME), IPS Universitaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Ubier E GómezCIEMTO [Drug and Poison Research and Information Center], Calle 64 # 51-31, Laboratorio Integrado de Medicina Especializada (LIME), IPS Universitaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Juliana QuinteroHospital Universitario San Vicente Fundación, Medellín, Colombia.
Andres F ZuluagaCIEMTO [Drug and Poison Research and Information Center], Calle 64 # 51-31, Laboratorio Integrado de Medicina Especializada (LIME), IPS Universitaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Antioquia, Colombia. andres.zuluaga@udea.edu.co.ORCID http://orcid.org/0000-0001-5656-4153
Universidad de Antioquia · COHospital Universitario de San Vicente Fundación · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute paraquat ingestion remains a leading cause of mortality in developing countries. There is currently no evidence that treatment with high-dose immunosuppressants and antioxidants improves survival in patients with paraquat poisoning, and better options are urgently needed. Here, we describe the unexpected survival and recovery of a patient with a potentially fatal paraquat poisoning. CASE PRESENTATION: After ingesting 28 mL of paraquat (20% ion w/v), confirmed by a deep blue color in the urine dithionite test (UDT), a 17-year-old Hispanic Colombian boy was treated according to the hospital protocol with cyclophosphamide, methylprednisolone, N-acetylcysteine, vitamin E and propranolol. Gastrointestinal endoscopy showed extensive ulceration and necrosis. As a novelty, enoxaparin at a single dose of 60 mg was added to his treatment. Despite the evidence of severe mucosal burns in the gastrointestinal tract and high paraquat concentrations found in the UDT, the clinical condition began to improve after 1 day of treatment, with full recovery and discharge from hospital after 21 days.

conclusionsAlthough the amount of paraquat ingested by the patient was large and the UDT indicated severe poisoning with a somber prognosis, unexpected survival of the patient was observed, and the addition of enoxaparin was the only change from the standard treatment.

Indexed as

Heparin, Low-Molecular-WeightParaquatAdolescentCyclophosphamideHumansImmunosuppressive AgentsMaleMethylprednisoloneCyclophosphamideHeparin, Low-Molecular-WeightImmunosuppressive AgentsMethylprednisoloneParaquatEnoxaparinParaquatPoisoningToxicity

Identifiers

PMID33287885
PMCPMC7722312
OpenAlexW3111957035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.