Evidence map›Paper›PMID 33287856›Full record

ArticleLipids in health and disease2020

The associations between p,p'-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content.

Juliann Jugan, P Monica Lind, Samira Salihovic, Jordan Stubleski, Anna Kärrman, Lars Lind, Michele A La Merrill

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Juliann JuganDepartment of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA, 95616, USA.
P Monica LindDepartment of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
Samira SalihovicSchool of Medical Sciences, Inflammatory Response and Infection Susceptibility Centre, Örebro University, Örebro, Sweden.
Jordan StubleskiWellington Laboratories Inc., Guelph, ON, Canada.
Anna KärrmanMTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden.
Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Michele A La MerrillDepartment of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA, 95616, USA. mlamerrill@ucdavis.edu.ORCID http://orcid.org/0000-0002-5720-5862
Örebro University · SEUniversity of California, Davis · USUppsala University · SE

Funding

ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
Perinatal DDT causes insulin resistance in mice through impaired thermogenesisR01ES024946 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LA MERRILL, MICHELE A · 2016 to 2020
$1.9M
NIEHS NIH HHS R01 ES024946NIEHS NIH HHS T32 ES007059
6 · The paper itself

Abstract

backgroundLipoproteins at aberrant levels are known to play a role in cardiovascular disease. The metabolite of the insecticide dichlorodiphenyltrichloroethane (DDT), p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), physically associates with lipids and accumulates in adipose tissue. Little is known about which lipoproteins associate with p,p'-DDE. An association between p,p'-DDE exposure and altered levels of circulating lipids was assessed in a large human cohort using a detailed analysis of lipoprotein content.

methodsPlasma samples were collected from the subset of 75-year old Swedes in the Prospective Investigation of the Vasculature of Uppsala Seniors (PIVUS) cohort who were not prescribed lipid lowering medication (n = 571). p,p'-DDE concentrations in plasma were measured using high-throughput solid phase extraction and gas chromatography-high resolution mass spectrometry. Analysis of plasma lipoprotein content was performed with nuclear magnetic resonance spectroscopy.

resultsDetectable levels of p,p'-DDE were found in the plasma samples of all subjects. Elevated p,p'-DDE levels were associated with increased concentrations of lipoproteins of all diameters, with the exception of high density lipoprotein (HDL) of diameters between 14.3 nm-10.9 nm. Of the lipoprotein constituents, triglycerides were most uniformly associated with elevated p,p'-DDE across lipoproteins. p,p'-DDE was furthermore associated with apolipoprotein B, but not apolipoprotein A1.

conclusionsThe positive associations observed between each lipoprotein class and elevated p,p'-DDE support previous data suggesting that p,p'-DDE interacts with lipoproteins within plasma. It is speculated that both physio-chemical and biological mechanisms may explain why p,p'-DDE does not uniformly associate with lipids across lipoproteins.

Indexed as

AgedAged, 80 and overApolipoprotein A-IApolipoprotein B-100DDTDichlorodiphenyl DichloroethyleneFemaleHumansInsecticidesLipidsLipoproteinsLipoproteins, HDLMagnetic Resonance SpectroscopyMaleRisk FactorsSurveys and QuestionnairesAPOA1 protein, humanAPOB protein, humanApolipoprotein A-IApolipoprotein B-100DDTDichlorodiphenyl DichloroethyleneInsecticidesLipidsLipoproteinsLipoproteins, HDLCardiovascular diseaseCholesterolDichlorodiphenyldichloroethyleneLipoproteinPersistent organic pollutantsPhospholipidsTriglycerides

Identifiers

PMID33287856
PMCPMC7722417
OpenAlexW3112778984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.