Evidence map›Paper›PMID 33287844›Full record

ArticleHead & face medicine2020

A collagen membrane influences bone turnover marker in vivo after bone augmentation with xenogenic bone.

Henning Staedt, Michael Dau, Eik Schiegnitz, Daniel G E Thiem, Olga Tagadiuc, Victor Palarie, Peter Ottl, Bilal Al-Nawas, Peer W Kämmerer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & face medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Henning StaedtPrivate Practice, Esslingen am Neckr, Germany.
Michael DauDepartment of Oral, Maxillofacial Plastic Surgery, University Medical Center Rostock, Schillingallee 35, 18057, Rostock, Germany.
Eik SchiegnitzDepartment of Oral, Maxillofacial Plastic Surgery, University Medical Center Mainz, Augustusplatz 2, 55131, Mainz, Germany.
Daniel G E ThiemDepartment of Oral, Maxillofacial Plastic Surgery, University Medical Center Mainz, Augustusplatz 2, 55131, Mainz, Germany.
Olga TagadiucLaboratory of Biochemistry, State University of Medicine and Pharmacy "Nicolae Testemitanu", Stefan cel Mare si Sfant Boulevard 165, 2004, Chisinau, Moldova.
Victor PalarieLaboratory of Tissue Engineering and Cell Cultures, State University of Medicine and Pharmacy "Nicolae Testemitanu", Stefan cel Mare si Sfant Boulevard 165, 2004, Chisinau, Moldova.
Peter OttlDepartment of Prosthodontics and Materials Science, University Medical Center Rostock, Strempelstraße 13, 18057, Rostock, Germany.
Bilal Al-NawasDepartment of Oral, Maxillofacial Plastic Surgery, University Medical Center Mainz, Augustusplatz 2, 55131, Mainz, Germany.
Peer W KämmererDepartment of Oral, Maxillofacial Plastic Surgery, University Medical Center Mainz, Augustusplatz 2, 55131, Mainz, Germany. peer.kaemmerer@unimedizin-mainz.de.
Johannes Gutenberg University Mainz · DENicolae Testemițanu State University of Medicine and Pharmacy · MDUniversity of Rostock · DEKlinikum Esslingen · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim was to compare early biochemical and histological osseous healing of chronic mandibular defects regenerated with bovine bone substitute with and without collagen membrane in vivo.

methodsEight weeks after formation of a lateral full-thickness perforating bone defect in the mandible of 40 rabbits, bovine bone substitute with ("+";n = 20) and without ("-";n = 20) collagen membrane was applied. Blood and bone was collected 24, 72 h, 7, 14 and 21 days after surgery. Total acid phosphatase, bone acid phosphatase, total alkaline phosphatase and bone alkaline phosphatase activities were compared between groups. Formation of new bone was quantified histologically for all time points.

resultsTwenty-four hours after surgery, bone alkaline phosphatase was significantly elevated in "+" group when compared to "-" (p=0.012). After 72 hours, all bone turnover markers except for total acid phosphatase (p=0.078) where significantly elevated in "+" (all p < 0.05). Fourteen days after surgery, the significant highest values for all bone turnover markers were detected in "-" (all p < 0.05). A significant difference in favor of group "-" could also be detected after 3 weeks in terms of both acid phosphatases (p < 0.05). In histology, no significant differences could be detected.

conclusionBone regeneration with bovine bone substitute material and collagen membrane shows a significantly earlier bone remodeling activity but does not seem to influence formation of new bone in histological samples.

Indexed as

Bone RemodelingBone SubstitutesAnimalsBone RegenerationCattleCollagenMembranesRabbitsBone SubstitutesCollagenAnimal studyBone regenerationBone remodelingCollagenMembraneSerological bone turnover markers

Identifiers

PMID33287844
PMCPMC7722310
OpenAlexW3113182744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.