Evidence map›Paper›PMID 33287817›Full record

ArticleEnvironmental health : a global access science source2020

DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter.

Congrong Wang, Michelle Plusquin, Akram Ghantous, Zdenko Herceg, Rossella Alfano, Bianca Cox, Tim S Nawrot

Open access · goldAbstract read
In one paragraph

Article in Environmental health : a global access science source, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Trimester-specific exposure to PMBMC pregnancy and childbirth · 2026
    Article
  3. Review
  4. Article
  5. Prenatal black carbon exposure and DNA methylation in umbilical cord blood.International journal of hygiene and environmental health · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Association of Prematurity and Low Birth Weight with Gestational Exposure to PMInternational journal of environmental research and public health · 2022
    Article
  14. Article
  15. Interaction of PMFrontiers in endocrinology · 2022
    Article
  16. Frontiers in cell and developmental biology · 2022
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Congrong WangCentre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, 3590 Diepenbeek, Hasselt, Belgium.
Michelle PlusquinCentre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, 3590 Diepenbeek, Hasselt, Belgium.
Akram GhantousEpigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France.
Zdenko HercegEpigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France.
Rossella AlfanoCentre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, 3590 Diepenbeek, Hasselt, Belgium.
Bianca CoxCentre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, 3590 Diepenbeek, Hasselt, Belgium.
Tim S NawrotCentre for Environmental Sciences, Hasselt University, Agoralaan gebouw D, 3590 Diepenbeek, Hasselt, Belgium. tim.nawrot@uhasselt.be.ORCID 0000-0002-3583-3593
Hasselt University · BECentre international de recherche sur le cancer · FR

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundThe IGF2 (insulin-like growth factor 2) and H19 gene cluster plays an important role during pregnancy as it promotes both foetal and placental growth. We investigated the association between cord blood DNA methylation status of the IGF2/H19 gene cluster and maternal fine particulate matter exposure during fetal life. To the best of our knowledge, this is the first study investigating the association between prenatal PM

methodsCord blood DNA methylation status of IGF2/H19 cluster was measured in 189 mother-newborn pairs from the ENVIRONAGE birth cohort (Flanders, Belgium). We assessed the sex-specific association between residential PM

resultsPrenatal PM

conclusionsThe results of our study provided evidence that prenatal PM

Indexed as

Maternal ExposureMaternal-Fetal ExchangeAdultAir PollutantsAir PollutionDNA MethylationFemaleFetal BloodHumansInfant, NewbornInsulin-Like Growth Factor IIMaleMultigene FamilyParticulate MatterPregnancyRNA, Long NoncodingAir PollutantsH19 long non-coding RNAIGF2 protein, humanInsulin-Like Growth Factor IIParticulate MatterRNA, Long NoncodingAir pollutionDLNMFactor analysisFetal growthGestationH19IGF2Imprinted genesMethylationNewbornPM2.5

Identifiers

PMID33287817
PMCPMC7720562
OpenAlexW3112942955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.