Evidence map›Paper›PMID 33287755›Full record

ArticleBMC pregnancy and childbirth2020

Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with gestational diabetes mellitus.

Yinglei Xu, Chunlian Wei, Cuijiao Wu, Mengmeng Han, Jingli Wang, Huabin Hou, Lu Zhang, Shiguo Liu, Ying Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yinglei XuDepartment of Medical Genetics, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Chunlian WeiDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100000, China.
Cuijiao WuDepartment of Histology and Embryology, Qingdao University Medical College, Qingdao, 260000, China.
Mengmeng HanDepartment of Medical Genetics, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Jingli WangDepartment of Medical Genetics, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Huabin HouDepartment of Clinical laboratory, the Affiliated Hospital of Qingdao University, Qingdao, China.
Lu ZhangDepartment of Medical Genetics, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Shiguo LiuDepartment of Medical Genetics, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China. liushiguo2002@126.com.
Ying ChenDepartment of Endocrinology and Metabolism, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China. 18661801696@163.com.
Affiliated Hospital of Qingdao University · CNQingdao University · CNCapital Medical University · CN

Funding

Key research and development plan of Shandong Province 2019GSF108106Natural Science Fund Project of Shandong Province ZR2019MH127the Application and Basic Research Project of Qingdao 18-2-2-27-jch
6 · The paper itself

Abstract

backgroundGestational diabetes mellitus (GDM) is a pregnancy-specific carbohydrate intolerance Which can cause a large number of perinatal and postpartum complications. The members of Transforming growth factor-β (TGF-β) superfamily play key roles in the homeostasis of pancreatic β-cell and may involve in the development of GDM. This study aimed to explore the association between the polymorphisms of TGF-β1, TGF-β3 and the risk to GDM in Chinese women.

methodsThis study included 919 GDM patients (464 with preeclampsia and 455 without preeclampsia) and 1177 healthy pregnant women. TaqMan allelic discrimination real-Time PCR was used to genotype the TGF-β1 (rs4803455) and TGF-β3 (rs2284792 and rs3917201), The Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test.

resultsAn increased frequency of TGF-β3 rs2284792 AA and AG genotype carriers was founded in GDM patients (AA vs. AG + GG: χ

conclusionsThe AA and AG genotype of TGF-β3 rs2284792 polymorphism may be significantly associated with increased risk of GDM in Chinese population.

Indexed as

AdultCase-Control StudiesChinaDiabetes, GestationalFemaleGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotidePre-EclampsiaPregnancyTransforming Growth Factor beta1Transforming Growth Factor beta3TGFB1 protein, humanTransforming Growth Factor beta1Transforming Growth Factor beta3GDMPEPolymorphismTGF-β1TGF-β3

Identifiers

PMID33287755
PMCPMC7720537
OpenAlexW3113214486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.