Evidence map›Paper›PMID 33287748›Full record

ArticleBMC psychiatry2020

Differences in course of illness between patients with bipolar II disorder with and without epileptiform discharges or other sharp activity on electroencephalograms: a cross-sectional study.

O K Drange, S G Sæther, P I Finseth, G Morken, A E Vaaler, V Arntsen, O Henning, O A Andreassen, T Elvsåshagen, U F Malt and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00201526 (Bipolar Research And Innovation Network - BRAIN), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00201526 recruitingnot on this map

Bipolar Research And Innovation Network - BRAIN

TypeobservationalSponsorNorwegian University of Science and TechnologyRan2003 to 2030Enrolled3,000ConditionsBipolar Disorder
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

O K DrangeDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway. ole.kristian.drange@gmail.com.ORCID 0000-0003-2766-7190
S G SætherDivision of Mental Health, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
P I FinsethDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
G MorkenDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
A E VaalerDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
V ArntsenDepartment of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
O HenningNational Center for Epilepsy, Oslo University Hospital, Oslo, Norway.
O A AndreassenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
T ElvsåshagenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
U F MaltInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
E BøenPsychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Oslo University Hospital · NONorwegian University of Science and Technology · NOSt Olav's University Hospital · NO

Funding

South-Eastern Norway Regional Health Authority 2015-078
6 · The paper itself

Abstract

backgroundA diagnosis of bipolar II disorder requires that the symptoms cannot be better explained by a medical condition. Epilepsy is in some cases associated with an affective syndrome mimicking an unstable bipolar II disorder. Epileptiform discharges on electroencephalograms (EEGs) are typical, but not pathognomonic, for epilepsy. A previous study has found a high frequency of epileptiform discharges and other sharp activity among patients with bipolar disorder. The aim of the study was to identify if epileptic discharges or other sharp activity per se are associated with an altered course of illness among patients with bipolar II disorder.

methodsEighty six patients diagnosed with bipolar II disorder at two psychiatric departments were interviewed about prior course of illness and assessed with EEGs. The patients were split into two groups based on the presence (n = 12) or absence (n = 74) of epileptiform discharges or other sharp activity. Wilcoxon rank sum test, Fisher's exact test, and Pearson's chi squared test were used to assess differences between the groups on six variables of course of illness.

resultsPatients with epileptiform discharges or other sharp activity had a history of more hypomanic episodes per year (median (interquartile range (IQR)) 1.5 (3.2) vs. 0.61 (1.1), p = 0.0090) and a higher hypomania:depression ratio (median (IQR) 3.2 (16) vs. 1.0 (1.0), p = 0.00091) as compared to patients without. None of the patients with epileptiform discharges or other sharp activity had self-reported epileptic seizures in their history.

conclusionsEpileptiform discharges or other sharp activity on EEGs are associated with more hypomanic episodes and an increased hypomania:depression ratio. Our results warrant replication in prospective studies, but suggest that EEG findings could be of prognostic importance for patients diagnosed with bipolar II disorder in psychiatric care.

trial registrationClinicalTrials.gov ( NCT00201526 ).

Indexed as

Bipolar DisorderEpilepsyCross-Sectional StudiesElectroencephalographyHumansProspective StudiesBipolar disorderElectroencephalographyEpileptiform dischargesSharp activity

Identifiers

PMID33287748
PMCPMC7720555
OpenAlexW3113024957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.