ArticleBMC genomics2020
Different classes of small RNAs are essential for head regeneration in the planarian Dugesia japonica.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Molecular Mechanism of Metformin Regulating the Regeneration of PlanarianInternational journal of molecular sciences · 2025Article
- Mining of potentially stem cell-related miRNAs in planarians.Molecular biology reports · 2024Review
- Conserved Genes in Highly Regenerative Metazoans Are Associated with Planarian Regeneration.Genome biology and evolution · 2024Article
- Transcriptional landscape of small non-coding RNAs reveals diversity of categories and functions in molluscs.RNA biology · 2024Article
- Transposon control as a checkpoint for tissue regeneration.Development (Cambridge, England) · 2022Article
- The Small RNA Universe ofFrontiers in molecular biosciences · 2022Article
- A Review of Discovery Profiling of PIWI-Interacting RNAs and Their Diverse Functions in Metazoans.International journal of molecular sciences · 2021Review
- miR-8b is involved in brain and eye regeneration of Dugesia japonica in head regeneration.Biology open · 2021Article
- Role ofFrontiers in cellular and infection microbiology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundPlanarians reliably regenerate all body parts after injury, including a fully functional head and central nervous system. But until now, the expression dynamics and functional role of miRNAs and other small RNAs during the process of head regeneration are not well understood. Furthermore, little is known about the evolutionary conservation of the relevant small RNAs pathways, rendering it difficult to assess whether insights from planarians will apply to other taxa.
resultsIn this study, we applied high throughput sequencing to identify miRNAs, tRNA fragments and piRNAs that are dynamically expressed during head regeneration in Dugesia japonica. We further show that knockdown of selected small RNAs, including three novel Dugesia-specific miRNAs, during head regeneration induces severe defects including abnormally small-sized eyes, cyclopia and complete absence of eyes.
conclusionsOur findings suggest that a complex pool of small RNAs takes part in the process of head regeneration in Dugesia japonica and provide novel insights into global small RNA expression profiles and expression changes in response to head amputation. Our study reveals the evolutionary conserved role of miR-124 and brings further promising candidate small RNAs into play that might unveil new avenues for inducing restorative programs in non-regenerative organisms via small RNA mimics based therapies.
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