Evidence map›Paper›PMID 33287625›Full record

Observational studyJournal of the American Heart Association2020

Risk Factor Burden and Long-Term Prognosis of Patients With Premature Coronary Artery Disease.

Michel Zeitouni, Robert M Clare, Karen Chiswell, Jawan Abdulrahim, Nishant Shah, Neha P Pagidipati, Svati H Shah, Matthew T Roe, Manesh R Patel, W Schuyler Jones

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 3 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 3 syntheses or guidelines pooled it, 150 citations in OpenAlex.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Michel ZeitouniDuke Clinical Research Institute Duke University School of Medicine Durham NC.
Robert M ClareDuke Clinical Research Institute Duke University School of Medicine Durham NC.
Karen ChiswellDuke Clinical Research Institute Duke University School of Medicine Durham NC.
Jawan AbdulrahimDuke Molecular Physiology Institute Durham NC.
Nishant ShahDuke Clinical Research Institute Duke University School of Medicine Durham NC.
Neha P PagidipatiDuke Clinical Research Institute Duke University School of Medicine Durham NC.
Svati H ShahDuke Clinical Research Institute Duke University School of Medicine Durham NC.
Matthew T RoeDuke Clinical Research Institute Duke University School of Medicine Durham NC.
Manesh R PatelDuke Clinical Research Institute Duke University School of Medicine Durham NC.
W Schuyler JonesDuke Clinical Research Institute Duke University School of Medicine Durham NC.
Duke University · USDuke Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Coronary artery disease (CAD) is increasing among young adults. We aimed to describe the cardiovascular risk factors and long-term prognosis of premature CAD. Methods and Results Using the Duke Databank for Cardiovascular Disease, we evaluated 3655 patients admitted between 1995 and 2013 with a first diagnosis of obstructive CAD before the age of 50 years. Major adverse cardiovascular events (MACEs), defined as the composite of death, myocardial infarction, stroke, or revascularization, were ascertained for up to 10 years. Cox proportional hazard regression models were used to assess associations with the rate of first recurrent event, and negative binomial log-linear regression was used for rate of multiple event recurrences. Past or current smoking was the most frequent cardiovascular factor (60.8%), followed by hypertension (52.8%) and family history of CAD (39.8%). Within a 10-year follow-up, 52.9% of patients had at least 1 MACE, 18.6% had at least 2 recurrent MACEs, and 7.9% had at least 3 recurrent MACEs, with death occurring in 20.9% of patients. Across follow-up, 31.7% to 37.2% of patients continued smoking, 81.7% to 89.3% had low-density lipoprotein cholesterol levels beyond the goal of 70 mg/dL, and 16% had new-onset diabetes mellitus. Female sex, diabetes mellitus, chronic kidney disease, multivessel disease, and chronic inflammatory disease were factors associated with recurrent MACEs. Conclusions Premature CAD is an aggressive disease with frequent ischemic recurrences and premature death. Individuals with premature CAD have a high proportion of modifiable cardiovascular risk factors, but failure to control them is frequently observed.

Indexed as

AdultCholesterolCoronary Artery DiseaseDiabetes MellitusFemaleFollow-Up StudiesGlobal Burden of DiseaseHeart Disease Risk FactorsHeterozygoteHospitalizationHumansHyperlipoproteinemia Type IIMaleMiddle AgedMortality, PrematureMyocardial InfarctionCholesterolcholesterolheterozygous familial hypercholesterolemialong‐term evolutionpremature coronary artery disease

Identifiers

PMID33287625
PMCPMC7955368
OpenAlexW3111698177

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.