Evidence map›Paper›PMID 33287388›Full record

ArticleMolecules (Basel, Switzerland)2020

An Insight into the Mechanism of Holamine- and Funtumine-Induced Cell Death in Cancer Cells.

Jelili A Badmus, Okobi E Ekpo, Jyoti R Sharma, Nicole Remaliah S Sibuyi, Mervin Meyer, Ahmed A Hussein, Donavon C Hiss

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. The Cytotoxicity ofCurrent issues in molecular biology · 2023
    Article
  3. Article
  4. Chemistry and bioactivities of natural steroidal alkaloids.Natural products and bioprospecting · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jelili A BadmusDepartment of Medical Biosciences, University of the Western Cape, 7535 Bellville, Western Cape, South Africa.ORCID 0000-0003-4785-2609
Okobi E EkpoDepartment of Medical Biosciences, University of the Western Cape, 7535 Bellville, Western Cape, South Africa.ORCID 0000-0003-3193-7499
Jyoti R SharmaDSI/Mintek-Nanotechnology Innovation Centre-BioLabels Node, Department of Biotechnology, University of the Western Cape, 7535 Bellville, Western Cape, South Africa.
Nicole Remaliah S SibuyiDSI/Mintek-Nanotechnology Innovation Centre-BioLabels Node, Department of Biotechnology, University of the Western Cape, 7535 Bellville, Western Cape, South Africa.ORCID 0000-0001-7175-5388
Mervin MeyerDSI/Mintek-Nanotechnology Innovation Centre-BioLabels Node, Department of Biotechnology, University of the Western Cape, 7535 Bellville, Western Cape, South Africa.ORCID 0000-0002-8296-4860
Ahmed A HusseinDepartment of Chemistry, Cape Peninsula University of Technology, 7535 Bellville, Western Cape, South Africa.ORCID 0000-0002-3877-9959
Donavon C HissDepartment of Medical Biosciences, University of the Western Cape, 7535 Bellville, Western Cape, South Africa.
Mintek · ZAUniversity of the Western Cape · ZACape Peninsula University of Technology · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Holamine and funtumine, steroidal alkaloids with strong and diverse pharmacological activities are commonly found in the Apocynaceae family of

Indexed as

AlkaloidsAntineoplastic AgentsApoptosisCell Cycle CheckpointsCell DeathCell LineCell Line, TumorCell ProliferationHeLa CellsHolarrhenaHT29 CellsHumansMCF-7 CellsMitochondriaReactive Oxygen SpeciesAlkaloidsAntineoplastic AgentsReactive Oxygen SpeciesanticancerApocynaceaeapoptosisfuntumineholaminesteroidal alkaloids

Identifiers

PMID33287388
PMCPMC7730674
OpenAlexW3108134938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.