Synthesis of [

Peter Roselt, Carleen Cullinane, Wayne Noonan, Hassan Elsaidi, Peter Eu, Leonard I Wiebe

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 90% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Peter RoseltThe Centre for Molecular Imaging and Translational Research Laboratory, The Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia.ORCID 0000-0003-2310-5377

Carleen CullinaneThe Centre for Molecular Imaging and Translational Research Laboratory, The Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia.

Wayne NoonanThe Centre for Molecular Imaging and Translational Research Laboratory, The Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia.

Hassan ElsaidiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, El Sultan Hussein St. Azarita, Alexandria 21521, Egypt.

Peter EuThe Centre for Molecular Imaging and Translational Research Laboratory, The Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia.

Leonard I WiebeDepartment of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada.ORCID 0000-0002-7078-4379

Peter MacCallum Cancer Centre · AUAlexandria University · EGUniversity of Alberta · CA

Funding

Malaysian Palm Oil Board General

6 · The paper itself

Abstract

Vitamin E, a natural antioxidant, is of interest to scientists, health care pundits and faddists; its nutritional and biomedical attributes may be validated, anecdotal or fantasy. Vitamin E is a mixture of tocopherols (TPs) and tocotrienols (T-3s), each class having four substitutional isomers (α-, β-, γ-, δ-). Vitamin E analogues attain only low concentrations in most tissues, necessitating exacting invasive techniques for analytical research. Quantitative positron emission tomography (PET) with an F-18-labeled molecular probe would expedite access to Vitamin E's biodistributions and pharmacokinetics via non-invasive temporal imaging. (

Indexed as

AnimalsAntioxidantsCell Line, TumorFemaleFluoridesFluorine Radioisotopesgamma-TocopherolHumansIsotope LabelingMiceMice, Inbred BALB CMice, NudeMolecular ProbesOxidation-ReductionPositron-Emission TomographyRadiochemistryAntioxidantsFluoridesFluorine-18Fluorine Radioisotopesgamma-TocopherolMolecular ProbesRadiopharmaceuticalsTocotrienolsVitamin E[18F]F-γ-T-3antioxidantsF-18 positron emission tomography (F-18 PET)F-γ-T-3nutraceuticalsradiofluorinationtocopherol (TP)tocotrienol (T-3)Vitamin EVitamin E analoguesγ-T-3

Identifiers

PMID33287202

DOI10.3390/molecules25235700

PMCPMC7730577

OpenAlexW3107820346

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.