Evidence map›Paper›PMID 33287170›Full record

ArticleAntioxidants (Basel, Switzerland)2020

Discovery of Spilanthol Endoperoxide as a Redox Natural Compound Active against Mammalian Prx3 and

Rosine Dushime, Yunhuang Zhu, Hanzhi Wu, Daniel Saez, Kirtikar Shukla, Heather Brown-Harding, Maique W Biavatti, Kimberly J Nelson, Leslie B Poole, William T Lowther and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Rosine DushimeDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Yunhuang ZhuDepartment of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
Hanzhi WuDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Daniel SaezDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Kirtikar ShuklaDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-1789-4990
Heather Brown-HardingDepartment of Biology, Wake Forest University, Winston-Salem, NC 27157, USA.ORCID 0000-0001-9636-2345
Maique W BiavattiCentro de Ciências da Saúde, Departamento de Ciências Farmacêuticas, Bloco J/K, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.
Kimberly J NelsonDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Leslie B PooleDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
William T LowtherDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.ORCID 0000-0002-0246-1295
Paul B JonesDepartment of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
Cristina M FurduiDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Allen W TsangDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Wake Forest University · USUniversidade Federal de Santa Catarina · BR

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Structures &Redox Chemistry in Sulfinic Acid ReductionR01GM072866 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LOWTHER, W TODD · 2005 to 2014
$2.6M
New Oxidation-Sensing Probes to Evaluate Mitochondrial Dysfunction in Lung InjuryR33ES025645 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FURDUI, CRISTINA MARIA, KING, S BRUCE · 2017 to 2019
$1.5M
Center for Molecular Signaling Wake Forest University Microscopic Imaging CoreNCI NIH HHS P30 CA012197NIEHS NIH HHS R33 ES025645NIGMS NIH HHS R01 GM072866Wake Forest Center for Redox Biology and Medicine Pilot Funds
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chlamydia trachomatisdioxacmellamidemitochondriaperoxiredoxinPrx3spilantholspilanthol endoperoxide

Identifiers

PMID33287170
PMCPMC7761737
OpenAlexW3109200629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.