Evidence map›Paper›PMID 33287129›Full record

ArticleNutrients2020

A Theacrine-Based Supplement Increases Cellular NAD

Petey W Mumford, Shelby C Osburn, Carlton D Fox, Joshua S Godwin, Michael D Roberts

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. NADMolecular and cellular biochemistry · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Petey W MumfordSchool of Health Sciences, Lindenwood University, Saint Charles, MO 63301, USA.
Shelby C OsburnSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Carlton D FoxSchool of Health Sciences, Lindenwood University, Saint Charles, MO 63301, USA.
Joshua S GodwinSchool of Health Sciences, Lindenwood University, Saint Charles, MO 63301, USA.
Michael D RobertsSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-7359-5362
Lindenwood University · USAuburn University · US

Funding

Compound Solutions N/AJUVN3 Holdings N/A
6 · The paper itself

Abstract

There is evidence in rodents to suggest that theacrine-based supplements modulate tissue sirtuin activity as well as other biological processes associated with aging. Herein, we examined if a theacrine-based supplement (termed NAD3) altered sirtuin activity in vitro while also affecting markers of mitochondrial biogenesis. The murine C2C12 myoblast cell line was used for experimentation. Following 7 days of differentiation, myotubes were treated with 0.45 mg/mL of NAD3 (containing ~2 mM theacrine) for 3 and 24 h (

Indexed as

AnimalsBiomarkersCytokinesHumansMitochondriaMusclesMyoblastsNADNicotinamide PhosphoribosyltransferaseRNA, MessengerRodentiaSirtuin 1SirtuinsUric Acid1,3,7,9-tetramethyluric acidBiomarkersCytokinesNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanRNA, MessengerSirtuin 1SirtuinsUric AcidmitochondriamRNAssirtuinstheacrine

Identifiers

PMID33287129
PMCPMC7761648
OpenAlexW3107068580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.