Evidence map›Paper›PMID 33286013›Full record

ReviewEntropy (Basel, Switzerland)2020

Complexity Analysis of EEG, MEG, and fMRI in Mild Cognitive Impairment and Alzheimer's Disease: A Review.

Jie Sun, Bin Wang, Yan Niu, Yuan Tan, Chanjuan Fan, Nan Zhang, Jiayue Xue, Jing Wei, Jie Xiang

Open access · goldAbstract readReview
In one paragraph

Review in Entropy (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 148 citations in OpenAlex.

  1. Article
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  4. Decoding the mechanisms of amyloid-β in synaptic toxicity.Journal of Alzheimer's disease : JAD · 2026
    Review
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  19. Disrupted Brain Hierarchical Organization in Alzheimer's Disease Progression.medRxiv : the preprint server for health sciences · 2025
    Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jie SunCollege of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China.
Bin WangCollege of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China.
Yan NiuCollege of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China.
Yuan TanCollege of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China.
Chanjuan FanCollege of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China.
Nan ZhangCollege of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China.
Jiayue XueCollege of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China.
Jing WeiCollege of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China.
Jie XiangCollege of Information and Computer, Taiyuan University of Technology, Taiyuan 030024, China.
Taiyuan University of Technology · CN

Funding

China Postdoctoral Science Foundation 2016M601287National Natural Science Foundation of China 61503272, 61305142, and 61373101Natural Science Foundation of Shanxi 2015021090the Shanxi Provincial Foundation for Returned Scholars, China 2016-037
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a degenerative brain disease with a high and irreversible incidence. In recent years, because brain signals have complex nonlinear dynamics, there has been growing interest in studying complex changes in the time series of brain signals in patients with AD. We reviewed studies of complexity analyses of single-channel time series from electroencephalogram (EEG), magnetoencephalogram (MEG), and functional magnetic resonance imaging (fMRI) in AD and determined future research directions. A systematic literature search for 2000-2019 was performed in the Web of Science and PubMed databases, resulting in 126 identified studies. Compared to healthy individuals, the signals from AD patients have less complexity and more predictable oscillations, which are found mainly in the left parietal, occipital, right frontal, and temporal regions. This complexity is considered a potential biomarker for accurately responding to the functional lesion in AD. The current review helps to reveal the patterns of dysfunction in the brains of patients with AD and to investigate whether signal complexity can be used as a biomarker to accurately respond to the functional lesion in AD. We proposed further studies in the signal complexities of AD patients, including investigating the reliability of complexity algorithms and the spatial patterns of signal complexity. In conclusion, the current review helps to better understand the complexity of abnormalities in the AD brain and provide useful information for AD diagnosis.

Indexed as

Alzheimer’s diseasebiomarkerbrain signalscomplexitysingle-channel analysis

Identifiers

PMID33286013
PMCPMC7516672
OpenAlexW3007499076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.