Evidence map›Paper›PMID 33285891›Full record

ArticleEntropy (Basel, Switzerland)2020

Permutation Entropy and Statistical Complexity in Mild Cognitive Impairment and Alzheimer's Disease: An Analysis Based on Frequency Bands.

Ignacio Echegoyen, David López-Sanz, Johann H Martínez, Fernando Maestú, Javier M Buldú

Abstract read
In one paragraph

Article in Entropy (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ignacio EchegoyenLaboratory of Biological Networks, Centre for Biomedical Technology, Universidad Politécnica de Madrid (UPM), 28223 Madrid, Spain.ORCID 0000-0001-8016-7836
David López-SanzLaboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid (UPM), 28223 Madrid, Spain.
Johann H MartínezGrupo Interdisciplinar de Sistemas Complejos (GISC), 28911 Madrid, Spain.ORCID 0000-0002-3365-8189
Fernando MaestúLaboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid (UPM), 28223 Madrid, Spain.ORCID 0000-0002-3195-0071
Javier M BuldúLaboratory of Biological Networks, Centre for Biomedical Technology, Universidad Politécnica de Madrid (UPM), 28223 Madrid, Spain.

Funding

Ministerio de Economía y Competitividad FIS2017-84151-P
6 · The paper itself

Abstract

We present one of the first applications of Permutation Entropy (PE) and Statistical Complexity (SC) (measured as the product of PE and Jensen-Shanon Divergence) on Magnetoencephalography (MEG) recordings of 46 subjects suffering from Mild Cognitive Impairment (MCI), 17 individuals diagnosed with Alzheimer's Disease (AD) and 48 healthy controls. We studied the differences in PE and SC in broadband signals and their decomposition into frequency bands ( δ , θ , α and β ), considering two modalities: (i) raw time series obtained from the magnetometers and (ii) a reconstruction into cortical sources or regions of interest (ROIs). We conducted our analyses at three levels: (i) at the group level we compared SC in each frequency band and modality between groups; (ii) at the individual level we compared how the [PE, SC] plane differs in each modality; and (iii) at the local level we explored differences in scalp and cortical space. We recovered classical results that considered only broadband signals and found a nontrivial pattern of alterations in each frequency band, showing that SC does not necessarily decrease in AD or MCI.

Indexed as

Alzheimer’s diseasefrequency bandsmild cognitive impairmentpermutation entropyregions of intereststatistical complexity

Identifiers

PMID33285891
PMCPMC7516422

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.