SynthesisUrologia internationalis2021
Hyperbaric Oxygenation in the Treatment of Fournier's Gangrene: A Systematic Review.
Synthesis in Urologia internationalis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Hyperbaric oxygen therapy and Fournier's gangrene: a systematic review and meta-analysis.Medical gas research · 2026Pooled it
- Hyperbaric Oxygen Therapy Is Associated with Lower Mortality in Patients with Fournier's Gangrene: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- The role of negative-pressure wound therapy in Fournier's gangrene: Association with mortality.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Prediction of intensive care unit requirement and in-hospital mortality in Fournier's gangrene: a comparative analysis of conventional statistical and machine learning models.Updates in surgery · 2026Article
- Defining the Standard of Care in Fournier's Gangrene-An Umbrella Review.European urology open science · 2026Review
- Oxy-inflammation in hyperbaric oxygen therapy applications.European journal of translational myology · 2025Article
- Perianal tuberculosis presenting as a Fournier's gangrene.Clinical case reports · 2024Article
- The Antimicrobial Resistance Index and Fournier Gangrene Severity Index of Patients Diagnosed with Fournier's Gangrene in a Tertiary Hospital in North Eastern Romania.Medicina (Kaunas, Lithuania) · 2023Article
- Outcome of necrotizing fasciitis and Fournier's gangrene with and without hyperbaric oxygen therapy: a retrospective analysis over 10 years.World journal of emergency surgery : WJES · 2022Article
- Management of Fournier's gangrene during the Covid-19 pandemic era: make a virtue out of necessity.Basic and clinical andrology · 2022Article
- Progress in Multidisciplinary Treatment of Fournier's Gangrene.Infection and drug resistance · 2022Review
- Review
- Hyperbaric Oxygen Therapy for Reconstructive Urology Wounds: A Case Series.Research and reports in urology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFournier's gangrene (FG) is a sporadic, life-threatening, necrotizing infection affecting the perineum, perineal region, and genitals. Hyperbaric oxygenation (HBO) improves tissue perfusion and promotes angiogenesis and collagen synthesis. Despite these positive effects of HBO, the indication and the effects on outcome as adjunct therapy in FG remain controversial. Consequently, we decided to perform a systematic review to compare the treatment of FG with or without the use of HBO as an adjunct therapy. MATERIALS AND
methodsWe performed a systematic review following the recommendations provided in the Cochrane Handbook of systematic Reviews and the PRISMA reporting guidelines. Due to the paucity of data and a suspected lack of randomized controlled trials, we considered all the available information for this systematic review.
resultsThe literature search for primary studies yielded 79 results. Finally, 13 studies were considered, which included a total of 376 patients with FG, of whom 202 received HBO therapy. Five of these studies had a retrospective case-control design. However, these 5 studies included a total of 319 patients; 145 of these patients were treated with adjunct HBO therapy. Overall, this leads to a mortality rate of 16.6% in the HBO group and 25.9% in the non-HBO group. Overall, risk of bias was assessed as moderate to high.
conclusionsWe conclude that despite the risk of bias, HBO has potential as an adjunct in FG treatment, but it is challenging to carry out further studies, mainly due to the rareness of FG and availability of HBO.
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