Evidence map›Paper›PMID 33285254›Full record

ArticleBone2021

The influence of adult hip shape genetic variants on adolescent hip shape: Findings from a population-based DXA study.

Monika Frysz, Denis Baird, Jenny S Gregory, Richard M Aspden, Nancy E Lane, Claes Ohlsson, Ulrika Pettersson-Kymmer, David Karasik, Jonathan H Tobias, Lavinia Paternoster

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Genetics of osteoarthritis.Osteoarthritis and cartilage · 2022
    Review
  3. An update on methods for assessing bone quality and health in Cystic fibrosis.Journal of clinical & translational endocrinology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Monika FryszMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Electronic address: monika.frysz@bristol.ac.uk.
Denis BairdMedical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Jenny S GregoryCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.
Richard M AspdenCentre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.
Nancy E LaneCenter for Musculoskeletal Health, University of California Davis School of Medicine, Sacramento, CA, USA.
Claes OhlssonCentre of Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Drug Treatment, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Ulrika Pettersson-KymmerClinical Pharmacology, Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.
David KarasikHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Jonathan H TobiasMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Lavinia PaternosterMedical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
University of Bristol · GBUniversity of Aberdeen · GBHebrew SeniorLife · USMedical Research Council · GBSahlgrenska University Hospital · SEUmeå University · SEUniversity of California, Davis · US

Funding

Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/1Wellcome Trust 102215/2/13/2Wellcome Trust 105504/Z/14/Z
6 · The paper itself

Abstract

objectiveHip shape is a well-recognized risk factor for hip osteoarthritis (OA) and hip fracture. We aimed to investigate whether the genetic variants known to be associated with adult hip shape were also associated with adolescent hip shape.

methodsHip DXA scans, obtained in offspring from the Avon Longitudinal Study of Parents and Children (ALSPAC) at two time points (mean ages 13.8 and 17.8 years), were used to quantify hip morphology using a 53-point Statistical Shape Model (SSM). Principal component analysis was used to generate hip shape modes (HSMs). Genetic variants which had previously shown genome-wide significant association with specific HSMs in adults were tested for association with the same HSMs in adolescents (at each timepoint separately) using SNPTEST v2.

resultsComplete genotypic and phenotypic data were available for 3550 and 3175 individuals at 14 and 18 years, respectively. The strongest evidence for association with adolescent hip shape was for a variant located near SOX9 (rs2158915) with consistent effects across both time points for HSM1 (age 14: beta -0.05, p = 9.9 × 10

conclusionIn conclusion, variants implicated in endochondral bone formation appear to consistently influence hip shape between adolescence and adulthood, including those aspects related to risk of hip OA and/or fracture in later life.

Indexed as

Femur HeadOsteoarthritis, HipAbsorptiometry, PhotonAdolescentAdultBone DensityChildFemurHipHumansLongitudinal StudiesALSPACDXAGenetic associationHip fracture riskHip shapeOsteoarthritis

Identifiers

PMID33285254
PMCPMC7809624
OpenAlexW3108411592

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.