Evidence map›Paper›PMID 33285008›Full record

Trial reportAnaesthesia2021

Prothrombin complex concentrate vs. fresh frozen plasma in adult patients undergoing heart surgery - a pilot randomised controlled trial (PROPHESY trial).

L Green, N Roberts, J Cooper, S Agarwal, S J Brunskill, I Chang, R Gill, A Johnston, A A Klein, S Platton and 5 more

Open access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

L GreenBlizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.ORCID 0000-0003-4063-9768
N RobertsWilliam Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.
J CooperDepartment of Anaesthesia, Manchester Royal Infirmary, Manchester, UK.
S AgarwalSystematic Review Initiative, NHS Blood and Transplant, Oxford, UK.
S J BrunskillDepartment of Anaesthesia, University Hospital Southampton, Southampton, UK.
I ChangDepartment of Anaesthesia, Manchester Royal Infirmary, Manchester, UK.
R GillWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
A JohnstonDepartment of Anaesthesia, Royal Papworth Hospital, Cambridge, UK.
A A KleinDepartment of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
S PlattonDepartment of Cardiac Surgery, Barts Health NHS Trust, London, UK.
A RossiWilliam Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.
A SepehripourWilliam Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.
S StanworthDepartment of Anaesthesia, Barts Health NHS Trust, London, UK.
V MonkDepartment of Anaesthesia, Manchester Royal Infirmary, Manchester, UK.
B O'BrienDepartment of Anaesthesia, Barts Health NHS Trust, London, UK.
Queen Mary University of London · GBManchester Royal Infirmary · GBNHS Blood and Transplant · GBBarts Health NHS Trust · GBCleveland Clinic · USOxford University Hospitals NHS Trust · GBPapworth Hospital · GBUniversity Hospital Southampton NHS Foundation Trust · GB

Funding

Barts Charity, London MGU0481British Heart Foundation PG/17/82/33368
6 · The paper itself

Abstract

There is equipoise regarding the use of prothrombin complex concentrate vs. fresh frozen plasma in bleeding patients undergoing cardiac surgery. We performed a pilot randomised controlled trial to determine the recruitment rate for a large trial, comparing the impact of prothrombin complex concentrate vs. fresh frozen plasma on haemostasis (1 h and 24 h post-intervention), and assessing safety. Adult patients who developed bleeding within 24 h of cardiac surgery that required coagulation factor replacement were randomly allocated to receive prothrombin complex concentrate (15 IU.kg

Indexed as

Cardiac Surgical ProceduresPlasmaAdultAgedAged, 80 and overBlood Coagulation FactorsFemaleHumansMaleMiddle AgedPilot ProjectsPostoperative HemorrhageProspective StudiesTreatment OutcomeBlood Coagulation Factorsprothrombin complex concentratesbleedingcardiac surgeryFFPPCCrandomised trial

Identifiers

PMID33285008
PMCPMC8246985
OpenAlexW3111630416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.