Evidence map›Paper›PMID 33284894›Full record

ArticleInternational journal of clinical and experimental pathology2020

Increased sensitivity of BCR-ABL-induced B-ALL to imatinib by releasing leukemia B cell differentiation blockage.

Zi Wang, Yong Li, Xiaokai Lu, Jia Yuan, Qiang Qiu, Cong Pan

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zi WangDepartment of Oncology, Guizhou Provincial People's Hospital Guiyang 550002, China.
Yong LiDepartment of Oncology, Guizhou Provincial People's Hospital Guiyang 550002, China.
Xiaokai LuDepartment of Oncology, Guizhou Provincial People's Hospital Guiyang 550002, China.
Jia YuanDepartment of Oncology, Guizhou Provincial People's Hospital Guiyang 550002, China.
Qiang QiuState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu 610041, China.
Cong PanState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu 610041, China.
Guizhou Provincial People's Hospital · CNChengdu Medical College · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsIn B cell acute lymphocytic leukemia (B-ALL), B cells are blocked mainly at the pro/pre-B phase, making them poorly responsive to imatinib. We aimed to investigate whether it was possible to promote pro/pre-B cell maturation beyond this phase and make them sensitive to imatinib treatment by overexpressing immunoregulatory tyrosine activation motif (ITAM) with BCR-ABL in a Ph+ B-ALL mouse model. MATERIALS &

methodsPh+ B-ALL mouse models were induced by BCR-ABL using retroviral transduction/transplantation.

resultsOverexpression of ITAM promoted the differentiation of blocked pro/pre-B cells to B220+IgM+ and increased disease sensitivity to imatinib in mice. Btk deficiency accelerated the progression of BCR-ABL-induced B-ALL.

conclusionB-cell development blockage released by ITAM renders leukemia cells sensitive to imatinib treatment in BCR-ABL-induced B-ALL.

Indexed as

B-cell acute lymphocytic leukemiaBCRBCR-ABLBruton’s tyrosine kinaseimatinibimmunoregulatory tyrosine activation motif

Identifiers

PMID33284894
PMCPMC7716132
OpenAlexW3110856341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.