ArticleAnnals of internal medicine2021
Peripheral Neuropathy and All-Cause and Cardiovascular Mortality in U.S. Adults : A Prospective Cohort Study.
Article in Annals of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 4 of them syntheses that pooled it.
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Who cites it
154 citing papers in PubMed, 4 syntheses or guidelines pooled it, 284 citations in OpenAlex.
- The association between the triglyceride-glucose index and diabetic peripheral neuropathy: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Development and validation of a risk prediction model for early diabetic peripheral neuropathy based on a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- The association between distal symmetric polyneuropathy in diabetes with all-cause mortality - a meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Cardiac autonomic neuropathy and risk of cardiovascular disease and mortality in type 1 and type 2 diabetes: a meta-analysis.BMJ open diabetes research & care · 2021Pooled it
- Comparison of intraepidermal nerve fiber density and confocal corneal microscopy for neuropathy.Annals of clinical and translational neurology · 2024Trial
- Article
- Comparing the Diagnostic Characteristics of Neuropathy Questionnaires in Adults With Obesity.Journal of the peripheral nervous system : JPNS · 2026Article
- Convergent human genetic evidence implicates serine biosynthesis in diabetic peripheral neuropathy.medRxiv : the preprint server for health sciences · 2026Article
- Article
- The impact of obesity-related anthropometric indices on diabetic foot ulcer and mortality: analysis of a nationally representative sample.Hormones (Athens, Greece) · 2026Article
- Relationship between the advanced lung cancer inflammation index (ALI) and all-cause and cause-specific mortality among patients with chronic obstructive pulmonary disease (COPD): a population-based study.BMC pulmonary medicine · 2026Article
- Statin use and risk of periodontitis in US adults: A population-based cross-sectional study.Medicine · 2026Article
- Association between the triglyceride-glucose-frailty index and all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of the poverty-income ratio.Cardiovascular diabetology · 2026Article
- Prediction of diabetic peripheral neuropathy in type 2 diabetes using high-frequency ultrasound and shear-wave elastography of the median and tibial nerves: a nomogram study.European journal of medical research · 2026Article
- Elevated body roundness index and epilepsy prevalence: a cross-sectional study.Scientific reports · 2026Article
- Association between the Zhejiang University index and kidney stone risks in US adults: evidence from NHANES 2007-2018.American journal of clinical and experimental urology · 2026Article
- Age at menarche and adult obesity: A cross-sectional study using data from the 1999-2018 National Health and Nutrition Examination Survey.The Journal of international medical research · 2026Article
- Article
- Prevalence and determinants of peripheral neuropathy among older Malaysians: Insights from a community-based cross-sectional study.Journal of family medicine and primary care · 2026Article
- Article
94 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGrowing evidence indicates that peripheral neuropathy (PN) is common even in the absence of diabetes
objectiveTo assess the associations of PN with all-cause and cardiovascular mortality in the general adult population of the United States.
designProspective cohort study.
settingNHANES (National Health and Nutrition Examination Survey), 1999 to 2004.
participants7116 adults aged 40 years or older who had standardized monofilament testing for PN. MEASUREMENTS: Cox regression to evaluate the associations of PN with all-cause and cardiovascular mortality after adjustment for demographic and cardiovascular risk factors, overall and stratified by diabetes status.
resultsThe overall prevalence of PN (±SE) was 13.5% ± 0.5% (27.0% ± 1.4% in adults with diabetes and 11.6% ± 0.5% in adults without diabetes). During a median follow-up of 13 years, 2128 participants died, including 488 of cardiovascular causes. Incidence rates (per 1000 person-years) of all-cause mortality were 57.6 (95% CI, 48.4 to 68.7) in adults with diabetes and PN, 34.3 (CI, 30.3 to 38.8) in adults with PN but no diabetes, 27.1 (CI, 23.4 to 31.5) in adults with diabetes but no PN, and 13.0 (CI, 12.1 to 14.0) in adults with no diabetes and no PN. In adjusted models, PN was significantly associated with all-cause mortality (hazard ratio [HR], 1.49 [CI, 1.15 to 1.94]) and cardiovascular mortality (HR, 1.66 [CI, 1.07 to 2.57]) in participants with diabetes. In those without diabetes, PN was significantly associated with all-cause mortality (HR, 1.31 [CI, 1.15 to 1.50]), but the association between PN and cardiovascular mortality was not statistically significant after adjustment (HR, 1.27 [CI, 0.98 to 1.66]). LIMITATION: Prevalent cardiovascular disease was self-reported, and PN was defined by monofilament testing only.
conclusionPeripheral neuropathy was common and was independently associated with mortality in the U.S. population, even in the absence of diabetes. These findings suggest that decreased sensation in the foot may be an underrecognized risk factor for death in the general population. PRIMARY FUNDING SOURCE: National Institute of Diabetes and Digestive and Kidney Diseases and National Heart, Lung, and Blood Institute of the National Institutes of Health.
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