Evidence map›Paper›PMID 33284677›Full record

Trial reportAnnals of internal medicine2021

The Effects of Four Doses of Vitamin D Supplements on Falls in Older Adults : A Response-Adaptive, Randomized Clinical Trial.

Lawrence J Appel, Erin D Michos, Christine M Mitchell, Amanda L Blackford, Alice L Sternberg, Edgar R Miller, Stephen P Juraschek, Jennifer A Schrack, Sarah L Szanton, Jeanne Charleston and 12 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02166333 (Vitamin D Supplements to Prevent Falls in Older Adults), which is not on this map. Cited by 52 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 5 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02166333 naterminatednot on this map

Vitamin D Supplements to Prevent Falls in Older Adults: A Dose-Response Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2015 to 2019Enrolled688ConditionsVitamin D Deficiency, FallsArms200 IU/d cholecalciferol, 1000 IU/d cholecalciferol, 2000 IU/d cholecalciferol, 4000 IU/d cholecalciferol
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 5 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Associations of Hypertension and Orthostatic Hypotension With Subclinical Cardiovascular Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Effects of Vitamin D on Physical Function: Results From the STURDY Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. The effects of vitamin D supplementation on types of falls.Journal of the American Geriatrics Society · 2021
    Trial
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Lawrence J AppelJohns Hopkins University, Baltimore, Maryland (L.J.A., E.R.M., D.L.R.).
Erin D MichosJohns Hopkins University School of Medicine, Baltimore, Maryland (E.D.M., A.L.B., R.R.K.).ORCID 0000-0002-5547-5084
Christine M MitchellJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (C.M.M., A.L.S., J.A.S., J.C., M.M., S.N.B., J.C., L.T.D., D.M.S., J.T.).ORCID 0000-0002-8211-281X
Amanda L BlackfordJohns Hopkins University School of Medicine, Baltimore, Maryland (E.D.M., A.L.B., R.R.K.).ORCID 0000-0002-6519-4833
Alice L SternbergJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (C.M.M., A.L.S., J.A.S., J.C., M.M., S.N.B., J.C., L.T.D., D.M.S., J.T.).
Edgar R MillerJohns Hopkins University, Baltimore, Maryland (L.J.A., E.R.M., D.L.R.).ORCID 0000-0003-0157-6258
Stephen P JuraschekBeth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts (S.P.J.).ORCID 0000-0003-4168-2696
Jennifer A SchrackJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (C.M.M., A.L.S., J.A.S., J.C., M.M., S.N.B., J.C., L.T.D., D.M.S., J.T.).ORCID 0000-0001-9244-9267
Sarah L SzantonJohns Hopkins University School of Nursing, Baltimore, Maryland (S.L.S.).ORCID 0000-0001-5418-4982
Jeanne CharlestonJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (C.M.M., A.L.S., J.A.S., J.C., M.M., S.N.B., J.C., L.T.D., D.M.S., J.T.).
Melissa MinottiJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (C.M.M., A.L.S., J.A.S., J.C., M.M., S.N.B., J.C., L.T.D., D.M.S., J.T.).ORCID 0000-0003-3488-226X
Sheriza N BakshJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (C.M.M., A.L.S., J.A.S., J.C., M.M., S.N.B., J.C., L.T.D., D.M.S., J.T.).ORCID 0000-0002-8341-860X
Robert H ChristensonUniversity of Maryland School of Medicine, Baltimore, Maryland (R.H.C., J.M.G.).
Josef CoreshJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (C.M.M., A.L.S., J.A.S., J.C., M.M., S.N.B., J.C., L.T.D., D.M.S., J.T.).ORCID 0000-0002-4598-0669
Lea T DryeJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (C.M.M., A.L.S., J.A.S., J.C., M.M., S.N.B., J.C., L.T.D., D.M.S., J.T.).
Jack M GuralnikUniversity of Maryland School of Medicine, Baltimore, Maryland (R.H.C., J.M.G.).
Rita R KalyaniJohns Hopkins University School of Medicine, Baltimore, Maryland (E.D.M., A.L.B., R.R.K.).
Timothy B PlanteLarner College of Medicine at the University of Vermont, Burlington, Vermont (T.B.P.).ORCID 0000-0001-9992-9597
David M ShadeJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (C.M.M., A.L.S., J.A.S., J.C., M.M., S.N.B., J.C., L.T.D., D.M.S., J.T.).
David L RothJohns Hopkins University, Baltimore, Maryland (L.J.A., E.R.M., D.L.R.).ORCID 0000-0003-2105-0536
James TonasciaJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (C.M.M., A.L.S., J.A.S., J.C., M.M., S.N.B., J.C., L.T.D., D.M.S., J.T.).
STURDY Collaborative Research Group
Johns Hopkins University · USUniversity of Maryland, Baltimore · USBeth Israel Deaconess Medical Center · USUniversity of Vermont · US

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
BEHAVIORAL RESEARCH IN HEART &VASCULAR DISEASET32HL007180 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MARUTHUR, NISA M · 1985 to 2020
$11.4M
Vitamin D Supplements to Prevent Falls in Older Adults: A Dose-Response TrialU01AG047837 · NIA · JOHNS HOPKINS UNIVERSITY · PI APPEL, LAWRENCE JOHN · 2014 to 2019
$9.5M
RENAL DISEASE EPIDEMIOLOGY TRAINING GRANTT32DK007732 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CREWS, DEIDRA CANDICE · 1995 to 2024
$7.7M
Vitamin D, Subclinical Cardiovascular Disease, and Orthostatic Hypotension in Older AdultsK23HL135273 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2017 to 2021
$1.1M
Glucose Insulin and Muscle LossK23DK093583 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI KALYANI, RITA R · 2012 to 2015
$635k
Energy Expenditure, Activity, and Aging With HIV:Effects on Functional LongevityK01AG048765 · NIA · JOHNS HOPKINS UNIVERSITY · PI SCHRACK, JENNIFER ANN · 2014 to 2016
$388k
NCATS NIH HHS UL1 TR003098NHLBI NIH HHS K23 HL135273NHLBI NIH HHS T32 HL007180NIA NIH HHS K01 AG048765NIA NIH HHS U01 AG047837NIDDK NIH HHS K23 DK093583NIDDK NIH HHS P30 DK072488NIDDK NIH HHS T32 DK007732
6 · The paper itself

Abstract

backgroundVitamin D supplementation may prevent falls in older persons, but evidence is inconsistent, possibly because of dosage differences.

objectiveTo compare the effects of 4 doses of vitamin D

design2-stage Bayesian, response-adaptive, randomized trial. (ClinicalTrials.gov: NCT02166333).

setting2 community-based research units.

participants688 participants, aged 70 years and older, with elevated fall risk and a serum 25-hydroxyvitamin D [25-(OH)D] level of 25 to 72.5 nmol/L.

intervention200 (control), 1000, 2000, or 4000 IU of vitamin D MEASUREMENTS: Time to first fall or death over 2 years (primary outcome).

resultsDuring the dose-finding stage, the primary outcome rates were higher for the 2000- and 4000-IU/d doses than for the 1000-IU/d dose, which was selected as the best dose (posterior probability of being best, 0.90). In the confirmatory stage, event rates were not significantly different between participants with experience receiving the best dose (events and observation time limited to the period they were receiving 1000 IU/d; LIMITATIONS: The control group received 200 IU of vitamin D

conclusionIn older persons with elevated fall risk and low serum 25-(OH)D levels, vitamin D PRIMARY FUNDING SOURCE: National Institute on Aging.

Indexed as

Dietary SupplementsAccidental FallsAgedBayes TheoremDrug Dosage CalculationsFemaleHumansMaleVitamin DVitamin D DeficiencyVitamins25-hydroxyvitamin DVitamin DVitamins

Identifiers

PMID33284677
PMCPMC8240534
OpenAlexW3112762342

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.