SynthesisCirculation. Genomic and precision medicine2021
Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease.
Abstract readLetterMeta-Analysis
In one paragraph
Synthesis in Circulation. Genomic and precision medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Mediation of coronary heart disease risk by genetic, socio-environmental, and lifestyle factors across racial groups.American journal of preventive cardiology · 2026Article
- Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Observational
- Striving Towards Equity in Cardiovascular Genomics Research.Current atherosclerosis reports · 2025Review
- Ancestry gaps in cardiovascular GWAS: a multi-database review of African representation in genomic studies.Frontiers in genetics · 2025Review
- Examining the Performance of Polygenic Risk Scores for Alzheimer Disease Within and Across Populations UsingNeurology. Genetics · 2024Article
- Assessing the predictive efficacy of European-based systolic blood pressure polygenic risk scores in diverse Brazilian cohorts.Scientific reports · 2024Article
- Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations.Human reproduction update · 2024Review
- Genome wide association study and genomic risk prediction of age related macular degeneration in Israel.Scientific reports · 2024Article
- Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.Circulation. Genomic and precision medicine · 2024Article
- Clinical applications of polygenic risk score for coronary artery disease through the life course.Atherosclerosis · 2023Review
- Pragmatic Approach to Applying Polygenic Risk Scores to Diverse Populations.Current protocols · 2023Article
- Polygenic Background Modifies Risk of Coronary Artery Disease Among Individuals With Heterozygous Familial Hypercholesterolemia.JACC. Advances · 2023Article
- Clinical utility of polygenic scores for cardiometabolic disease in Arabs.Nature communications · 2023Article
- Associations of cardiometabolic polygenic risk scores with cardiovascular disease in African Americans.Research square · 2023Article
- Article
- A Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization.medRxiv : the preprint server for health sciences · 2023Article
- Observational
- Diversity is key for cross-ancestry transferability of glaucoma genetic risk scores in Hispanic Veterans in the Million Veteran Program.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2023Article
- Earlier treatment in adults with high lifetime risk of cardiovascular diseases: What prevention trials are feasible and could change clinical practice? Report of a National Heart, Lung, and Blood Institute (NHLBI) Workshop.American journal of preventive cardiology · 2022Review
- Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events.Circulation. Genomic and precision medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Akl C FahedCentre for Genomic Medicine, Department of Medicine (A.C.F., A.V.K.), Massachusetts General Hospital.
Krishna G AragamDivision of Cardiology, Department of Medicine (A.C.F., K.G.A., P.T.E., S.K., A.V.K.), Massachusetts General Hospital.
George HindyDepartment of Population Medicine, College of Medicine, QU Health, Qatar University, Doha (G.H.).
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Centre, Torrance, CA (Y.-D.I.C., J.I.R.).
Kumardeep ChaudharyDepartment of Genetics and Genomic Sciences, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (K.C., A.D., J.C., R.D.).
Amanda DobbynDepartment of Genetics and Genomic Sciences, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (K.C., A.D., J.C., R.D.).
Harlan M KrumholzSection of Cardiovascular Medicine and the Robert Wood Johnson Clinical Scholars Program, Department of Medicine, Yale University School of Medicine, New Haven, CT (H.M.K.).
Wayne H H SheuDepartment of Medicine, Taichung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan (W.H.H.S.).
Stephen S RichCentre for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville (S.S.R.).
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Centre, Torrance, CA (Y.-D.I.C., J.I.R.).
Rajiv ChowdhuryDepartment of Public Health and Primary Care, University of Cambridge, United Kingdom (R.C.).
Judy ChoDepartment of Genetics and Genomic Sciences, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (K.C., A.D., J.C., R.D.).
Ron DoDepartment of Genetics and Genomic Sciences, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (K.C., A.D., J.C., R.D.).
Patrick T EllinorDivision of Cardiology, Department of Medicine (A.C.F., K.G.A., P.T.E., S.K., A.V.K.), Massachusetts General Hospital.
Sekar Kathiresan *Division of Cardiology, Department of Medicine (A.C.F., K.G.A., P.T.E., S.K., A.V.K.), Massachusetts General Hospital.
Amit V Khera *Centre for Genomic Medicine, Department of Medicine (A.C.F., A.V.K.), Massachusetts General Hospital.
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MCenter for Common Disease GeneticsUM1HG008895 · NHGRI · BROAD INSTITUTE, INC. · PI DALY, MARK JOSEPH, GABRIEL, STACEY · 2016 to 2020
$111.2MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MMedical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MTranslational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MMULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR001881NHGRI NIH HHS K08 HG010155NHGRI NIH HHS UM1 HG008895NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K24 HL105780NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL081153NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL139865NHLBI NIH HHS T32 HL007208NIDDK NIH HHS P30 DK063491NIGMS NIH HHS R35 GM124836NIGMS NIH HHS T32 GM007753
Abstract
PubMed holds no abstract for this paper.
Indexed as
Genome-Wide Association StudyAsian PeopleBlack PeopleCoronary Artery DiseaseHispanic or LatinoHumansOdds RatioRiskWhite Peoplecoronary artery diseasegeneticshumansmeta-analysisrace
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