Evidence map›Paper›PMID 33284436›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Measuring the Effects of Circadian Rhythm-Related Manipulations on Depression-Like Behavior in Rodents: Forced Swim and Tail Suspension Tests.

Chelsea A Vadnie, Lauren M DePoy, Colleen A McClung

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chelsea A VadnieDepartment of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Lauren M DePoyDepartment of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Colleen A McClungPsychiatry and Clinical and Translational Science, Translational Neuroscience Program, Center for Neuroscience University of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. mcclungca@upmc.edu.
University of Pittsburgh · US

Funding

Subject Management and BiobankingP50DA046346 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel J. Buysse, Colleen A McClung · 2020 to 2026
$23.4M
Translational Research Training in Sleep MedicineT32HL082610 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel J. Buysse, PETER L FRANZEN · 2007 to 2026
$5.8M
Role of NPAS2 in the nucleus accumbens in drug addictionR01DA039865 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCCLUNG, COLLEEN A · 2015 to 2024
$3.9M
Selective HDAC inhibition and therapeutic target genes: Identification of novel treatments for Bipolar DisorderR01MH106460 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCCLUNG, COLLEEN A · 2016 to 2024
$3.6M
Role of The Circadian Clock in the Development and Treatment of Mood DisordersR01MH082876 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI MCCLUNG, COLLEEN A · 2009 to 2013
$1.9M
Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2R01DA023988 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI MCCLUNG, COLLEEN A · 2009 to 2013
$1.9M
Impact of metabolic changes in response to chronic cocaine on circadian gene funcR21DA037636 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCCLUNG, COLLEEN A · 2014 to 2015
$420k
NHLBI NIH HHS T32 HL082610NIDA NIH HHS P50 DA046346NIDA NIH HHS R01 DA023988NIDA NIH HHS R01 DA039865NIDA NIH HHS R21 DA037636NIMH NIH HHS R01 MH082876NIMH NIH HHS R01 MH106460
6 · The paper itself

Abstract

The forced swim and tail suspension tests are commonly used to determine the effects of circadian-related pharmacological, genetic, and environmental manipulations on depression-like behavior in rodents. Both tests involve scoring immobility of rodents in an inescapable condition. Here we describe how to set up and carry out these tests.

Indexed as

Circadian RhythmAnimalsDepressionHindlimb SuspensionMicePhysical Conditioning, AnimalSwimmingAntidepressantDepressionForced swim testImmobilityMiceRatsTail suspension test

Identifiers

PMID33284436
PMCPMC10128615
OpenAlexW3112057953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.