ArticleeLife2020
Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortex.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- A standardized and reproducible behavioral framework to elicit multiple aspects of visual spatial attention in mice.Cell reports methods · 2026Article
- Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex.Neuron · 2026Article
- Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight.Current biology : CB · 2026Article
- Distinct roles of cortical layer 5 subtypes in associative learning.Nature communications · 2026Article
- Neuronal Features of Visual Attention in the Mouse Superior Colliculus Depend on Learned Behavioral Relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Atypical cortical feedback underlies failure to process contextual information in the superior colliculus of Scn2aNature communications · 2025Article
- Primary auditory cortex is necessary for the acquisition and expression of categorical behavior.Current biology : CB · 2025Article
- Dissociating instructive from permissive roles of brain circuits with reversible neural activity manipulations.bioRxiv : the preprint server for biology · 2025Article
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- Network influence determines the impact of cortical ensembles on stimulus detection.bioRxiv : the preprint server for biology · 2024Article
- The influence of cortical activity on perception depends on behavioral state and sensory context.Nature communications · 2024Article
- Auditory Corticofugal Neurons Transmit Auditory and Non-auditory Information During Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A direction-selective cortico-brainstem pathway adaptively modulates innate behaviors.Nature communications · 2023Article
- How deep is the brain? The shallow brain hypothesis.Nature reviews. Neuroscience · 2023Review
- All-optical recreation of naturalistic neural activity with a multifunctional transgenic reporter mouse.Cell reports · 2023Article
- Optimizing intact skull intrinsic signal imaging for subsequent targeted electrophysiology across mouse visual cortex.Scientific reports · 2022Article
- Article
- Neocortical layer 5 subclasses: From cellular properties to roles in behavior.Frontiers in synaptic neuroscience · 2022Review
- Probing mechanisms of visual spatial attention in mice.Trends in neurosciences · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrates can change their behavior upon detection of visual stimuli according to the outcome their actions produce. Such goal-directed behavior involves evolutionary conserved brain structures like the striatum and optic tectum, which receive ascending visual input from the periphery. In mammals, however, these structures also receive descending visual input from visual cortex (VC), via neurons that give rise to cortico-fugal projections. The function of cortico-fugal neurons in visually guided, goal-directed behavior remains unclear. Here, we address the impact of two populations of cortico-fugal neurons in mouse VC in the learning and performance of a visual detection task. We show that the ablation of striatal projecting neurons reduces learning speed, whereas the ablation of superior colliculus projecting neurons does not impact learning but reduces detection sensitivity. This functional dissociation between distinct cortico-fugal neurons in controlling learning speed and detection sensitivity suggests an adaptive contribution of cortico-fugal pathways even in simple goal-directed behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.