ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2021
Elevated serum ferritin level effectively discriminates severity illness and liver injury of coronavirus disease 2019 pneumonia.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Hematological and biochemical markers for predicting severity in COVID-19 patients.BMC infectious diseases · 2026Observational
- Analyzing the association between ferritin levels and ICP using machine learning algorithms: a retrospective case-control study.Frontiers in medicine · 2026Article
- Biomarkers as Beacons: Illuminating Sepsis-Associated Hepato-Renal Injury.International journal of molecular sciences · 2025Review
- Study on ferritin and liver injury in pediatric hemophagocytic lymphohistiocytosis associated with infection.Scientific reports · 2025Article
- Development and validation of a nomogram for predicting severe adenovirus pneumonia in children.Frontiers in pediatrics · 2025Article
- Review
- Amelioration effects of the soybean lecithin-gallic acid complex on iron-overload-induced oxidative stress and liver damage in C57BL/6J mice.Pharmaceutical biology · 2023Article
- Article
- Article
- Role of Serum Ferritin, D-Dimer, and C-Reactive Protein Parameters in COVID 19 Severity.Archives of Razi Institute · 2023Article
- Clinical progress in MSC-based therapies for the management of severe COVID-19.Cytokine & growth factor reviews · 2022Review
- Prognostic role of pretreatment serum ferritin concentration in lung cancer patients: A meta-analysis.World journal of clinical cases · 2022Article
- COVID-19 associated liver injury: A general review with special consideration of pregnancy and obstetric outcomes.World journal of gastroenterology · 2022Review
- Assessment of Clinical Profile and Treatment Outcome in Vaccinated and Unvaccinated SARS-CoV-2 Infected Patients.Vaccines · 2022Article
- Ferritin - from iron, through inflammation and autoimmunity, to COVID-19.Journal of autoimmunity · 2022Review
- Potential role of biochemical markers in the prognosis of COVID-19 patients.SAGE open medicine · 2022Review
- Genome-wide screening of SARS-CoV-2 infection-related genes based on the blood leukocytes sequencing data set of patients with COVID-19.Journal of medical virology · 2021Article
- Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain.Journal of clinical immunology · 2021Article
- Article
- Clinical Predictors of COVID-19 Mortality Among Patients in Intensive Care Units: A Retrospective Study.International journal of general medicine · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimFerritin is a hepatic protein that plays vital roles in diagnosing and predicting diseases, but its potential in coronavirus disease 2019 (COVID-19) remains unknown.
methodWe collected clinical records from 79 COVID-19 patients at Wuhan Union hospital (China). Spearman's correlation analysis, receiver operating characteristic (ROC) curve and Kaplan-Meier survival curves were employed.
resultsPatients with elevated ferritin levels had a higher incidence of severity illness (50.0 vs 2.9%) and liver injury (52.3 vs 20.0%) when compared with patients with normal ferritin levels (
conclusionsIt suggests that ferritin could act as an easy-to-use tool to identify liver injury and severity illness and predict the prognosis of COVID-19 patients. Intensive surveillance is necessary for patients with abnormal ferritin levels.
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