Evidence map›Paper›PMID 33283887›Full record

ArticleThe EMBO journal2021

Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.

Isabela Cunha Navarro, Francesca Tuorto, David Jordan, Carine Legrand, Jonathan Price, Fabian Braukmann, Alan G Hendrick, Alper Akay, Annika Kotter, Mark Helm and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Detection and Characterization of the Eukaryotic Vacant Ribosome.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Detection, molecular function and mechanisms of m5C in cancer.Clinical and translational medicine · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. The extensive mNature communications · 2024
    Article
  14. Transfer RNA acetylation regulates in vivo mammalian stress signaling.bioRxiv : the preprint server for biology · 2024
    Article
  15. Article
  16. Epigenetic addition of mCell death & disease · 2024
    Article
  17. Article
  18. Vital roles of mFrontiers in immunology · 2023
    Review
  19. The Thermal Stress Coping Network of the NematodeInternational journal of molecular sciences · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Isabela Cunha NavarroGurdon Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6844-2361
Francesca TuortoDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0003-1625-1181
David JordanGurdon Institute, University of Cambridge, Cambridge, UK.
Carine LegrandDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.
Jonathan PriceGurdon Institute, University of Cambridge, Cambridge, UK.
Fabian BraukmannGurdon Institute, University of Cambridge, Cambridge, UK.
Alan G HendrickSTORM Therapeutics Limited, Babraham Research Campus, Cambridge, UK.
Alper AkayGurdon Institute, University of Cambridge, Cambridge, UK.
Annika KotterInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Mainz, Germany.
Mark HelmInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University Mainz, Mainz, Germany.
Frank LykoDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.
Eric A MiskaGurdon Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0002-4450-576X
University of Cambridge · GBGerman Cancer Research Center · DEJohannes Gutenberg University Mainz · DEUniversity of East Anglia · GB

Funding

Cancer Research UK 11832Cancer Research UK 27826Cancer Research UK C13474/A27826Cancer Research UK C6946/A24843Medical Research Council MR/S033769/1Wellcome TrustWellcome Trust 092096/Z/10/ZWellcome Trust 104640/Z/14/ZWellcome Trust 203144/Z/16/Z
6 · The paper itself

Abstract

Methylation of carbon-5 of cytosines (m

Indexed as

5-MethylcytosineAdaptation, PhysiologicalAnimalsCaenorhabditis elegansCRISPR-Cas SystemsCytosineGene EditingHeat-Shock ResponseHot TemperatureLeucineMethyltransferasesMitochondriaProlineProtein BiosynthesisRibosomesRNA5-MethylcytosineCytosineLeucineMethyltransferasesProlineRNA5-methylcytosineCaenorhabditis elegansNSUNRNA modificationstranslation efficiency

Identifiers

PMID33283887
PMCPMC7957426
OpenAlexW3113111785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.